| http://purl.uniprot.org/citations/23974192 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23974192 | http://www.w3.org/2000/01/rdf-schema#comment | "Most relapses in childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL) are not predicted using current prognostic features. Here, we determined the co-occurrence and independent prognostic relevance of 3 recently identified prognostic features: BCR-ABL1-like gene signature, deletions in IKZF1, and high CRLF2 messenger RNA expression (CRLF2-high). These features were determined in 4 trials representing 1128 children with ALL: DCOG ALL-8, ALL9, ALL10, and Cooperative ALL (COALL)-97/03. BCR-ABL1-like, IKZF1-deleted, and CRLF2-high cases constitute 33.7% of BCR-ABL1-negative, MLL wild-type BCP-ALL cases, of which BCR-ABL1-like and IKZF1 deletion (co)occurred most frequently. Higher cumulative incidence of relapse was found for BCR-ABL1-like and IKZF1-deleted, but not CRLF2-high, cases relative to remaining BCP-ALL cases, reflecting the observations in each of the cohorts analyzed separately. No relapses occurred among cases with CRLF2-high as single feature, whereas 62.9% of all relapses in BCR-ABL1-negative, MLL wild-type BCP-ALL occurred in cases with BCR-ABL1-like signature and/or IKZF1 deletion. Both the BCR-ABL1-like signature and IKZF1 deletions were prognostic features independent of conventional prognostic markers in a multivariate model, and both remained prognostic among cases with intermediate minimal residual disease. The BCR-ABL1-like signature and an IKZF1 deletion, but not CRLF2-high, are prognostic factors and are clinically of importance to identify high-risk patients who require more intensive and/or alternative therapies."xsd:string |
| http://purl.uniprot.org/citations/23974192 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2012-10-462358"xsd:string |
| http://purl.uniprot.org/citations/23974192 | http://purl.uniprot.org/core/author | "Harrison C.J."xsd:string |
| http://purl.uniprot.org/citations/23974192 | http://purl.uniprot.org/core/author | "Evans W.E."xsd:string |
| http://purl.uniprot.org/citations/23974192 | http://purl.uniprot.org/core/author | "Sonneveld E."xsd:string |
| http://purl.uniprot.org/citations/23974192 | http://purl.uniprot.org/core/author | "Kuiper R.P."xsd:string |
| http://purl.uniprot.org/citations/23974192 | http://purl.uniprot.org/core/author | "Waanders E."xsd:string |
| http://purl.uniprot.org/citations/23974192 | http://purl.uniprot.org/core/author | "Pieters R."xsd:string |
| http://purl.uniprot.org/citations/23974192 | http://purl.uniprot.org/core/author | "Horstmann M.A."xsd:string |
| http://purl.uniprot.org/citations/23974192 | http://purl.uniprot.org/core/author | "Russell L.J."xsd:string |
| http://purl.uniprot.org/citations/23974192 | http://purl.uniprot.org/core/author | "Hoogerbrugge P.M."xsd:string |
| http://purl.uniprot.org/citations/23974192 | http://purl.uniprot.org/core/author | "van der Velden V.H."xsd:string |
| http://purl.uniprot.org/citations/23974192 | http://purl.uniprot.org/core/author | "Escherich G."xsd:string |
| http://purl.uniprot.org/citations/23974192 | http://purl.uniprot.org/core/author | "Den Boer M.L."xsd:string |
| http://purl.uniprot.org/citations/23974192 | http://purl.uniprot.org/core/author | "van der Veer A."xsd:string |
| http://purl.uniprot.org/citations/23974192 | http://purl.uniprot.org/core/author | "De Groot-Kruseman H.A."xsd:string |
| http://purl.uniprot.org/citations/23974192 | http://purl.uniprot.org/core/author | "Mohammadi Khankahdani L."xsd:string |
| http://purl.uniprot.org/citations/23974192 | http://purl.uniprot.org/core/author | "Rizopoulos D."xsd:string |
| http://purl.uniprot.org/citations/23974192 | http://purl.uniprot.org/core/author | "Van Leeuwen F."xsd:string |
| http://purl.uniprot.org/citations/23974192 | http://purl.uniprot.org/core/author | "Van Reijmersdal S.V."xsd:string |
| http://purl.uniprot.org/citations/23974192 | http://purl.uniprot.org/core/author | "Willemse M.E."xsd:string |
| http://purl.uniprot.org/citations/23974192 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23974192 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/23974192 | http://purl.uniprot.org/core/pages | "2622-2629"xsd:string |