| http://purl.uniprot.org/citations/23975195 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23975195 | http://www.w3.org/2000/01/rdf-schema#comment | "Despite their physiological importance, selective interactions between nuclear receptors (NRs) and their cofactors are poorly understood. Here, we describe a novel signature motif (F/YSXXLXXL/Y) in the developmental regulator BCL11A that facilitates its selective interaction with members of the NR2E/F subfamily. Two copies of this motif (named here as RID1 and RID2) permit BCL11A to bind COUP-TFs (NR2F1;NR2F2;NR2F6) and Tailless/TLX (NR2E1), whereas RID1, but not RID2, binds PNR (NR2E3). We confirmed the existence of endogenous BCL11A/TLX complexes in mouse cortex tissue. No interactions of RID1 and RID2 with 20 other ligand-binding domains from different NR subtypes were observed. We show that RID1 and RID2 are required for BCL11A-mediated repression of endogenous γ-globin gene and the regulatory non-coding transcript Bgl3, and we identify COUP-TFII binding sites within the Bgl3 locus. In addition to their importance for BCL11A function, we show that F/YSXXLXXL/Y motifs are conserved in other NR cofactors. A single FSXXLXXL motif in the NR-binding SET domain protein NSD1 facilitates its interactions with the NR2E/F subfamily. However, the NSD1 motif incorporates features of both LXXLL and FSXXLXXL motifs, giving it a distinct NR-binding pattern in contrast to other cofactors. In summary, our results provide new insights into the selectivity of NR/cofactor complex formation."xsd:string |
| http://purl.uniprot.org/citations/23975195 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/gkt761"xsd:string |
| http://purl.uniprot.org/citations/23975195 | http://purl.uniprot.org/core/author | "Mongan N.P."xsd:string |
| http://purl.uniprot.org/citations/23975195 | http://purl.uniprot.org/core/author | "Chan C.M."xsd:string |
| http://purl.uniprot.org/citations/23975195 | http://purl.uniprot.org/core/author | "Heery D.M."xsd:string |
| http://purl.uniprot.org/citations/23975195 | http://purl.uniprot.org/core/author | "Collins H.M."xsd:string |
| http://purl.uniprot.org/citations/23975195 | http://purl.uniprot.org/core/author | "Fulton J."xsd:string |
| http://purl.uniprot.org/citations/23975195 | http://purl.uniprot.org/core/author | "Wadelin F.R."xsd:string |
| http://purl.uniprot.org/citations/23975195 | http://purl.uniprot.org/core/author | "Montiel-Duarte C."xsd:string |
| http://purl.uniprot.org/citations/23975195 | http://purl.uniprot.org/core/author | "Moran P.M."xsd:string |
| http://purl.uniprot.org/citations/23975195 | http://purl.uniprot.org/core/author | "Bharti N."xsd:string |
| http://purl.uniprot.org/citations/23975195 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23975195 | http://purl.uniprot.org/core/name | "Nucleic Acids Res"xsd:string |
| http://purl.uniprot.org/citations/23975195 | http://purl.uniprot.org/core/pages | "9663-9679"xsd:string |
| http://purl.uniprot.org/citations/23975195 | http://purl.uniprot.org/core/title | "A signature motif mediating selective interactions of BCL11A with the NR2E/F subfamily of orphan nuclear receptors."xsd:string |
| http://purl.uniprot.org/citations/23975195 | http://purl.uniprot.org/core/volume | "41"xsd:string |
| http://purl.uniprot.org/citations/23975195 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23975195 |
| http://purl.uniprot.org/citations/23975195 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23975195 |
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| http://purl.uniprot.org/uniprot/#_D3YYP4-mappedCitation-23975195 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23975195 |
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| http://purl.uniprot.org/uniprot/#_A0A286YDS9-mappedCitation-23975195 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23975195 |