| http://purl.uniprot.org/citations/23975374 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23975374 | http://www.w3.org/2000/01/rdf-schema#comment | "Our previous studies have revealed that miR-148a is downregulated in pancreatic cancer. Bioinformatics analysis has shown cholecystokinin-B receptor (CCKBR) and B cell lymphoma (Bcl-2) to be potential targets of miR-148a. But the pathophysiologic role of miR-148a and its relevance to the growth and development of pancreatic cancer are yet to be investigated. The purpose of this study is to elucidate the molecular mechanisms where miR-148a acts as a tumor suppressor in pancreatic cancer. Our results showed significant downregulation of miR-148a in 28 pancreatic cancer tissue samples and five pancreatic cancer cell lines, compared with their non-tumor counterparts by qRT-PCR. MiR-148a was found to not only inhibit the proliferation of pancreatic cancer cells (PANC-1 and AsPC-1) in vitro by MTT assay and colony formation assay, but also to promote cells apoptosis in vitro by Annexin V-FITC apoptosis detection and caspase activity assay. Using western blot and luciferase activity assay, CCKBR and Bcl-2 were identified as targets of miR-148a. Moreover, we also found that the expression of Bcl-2 lacking in 3'UTR could abrogate the pro-apoptosis function of miR-148a. These findings suggest the importance of miR-148a's targeting of CCKBR and Bcl-2 in the regulation of pancreatic cancer growth and apoptosis."xsd:string |
| http://purl.uniprot.org/citations/23975374 | http://purl.org/dc/terms/identifier | "doi:10.1007/s13277-013-1115-2"xsd:string |
| http://purl.uniprot.org/citations/23975374 | http://purl.uniprot.org/core/author | "Chen X."xsd:string |
| http://purl.uniprot.org/citations/23975374 | http://purl.uniprot.org/core/author | "Du Y."xsd:string |
| http://purl.uniprot.org/citations/23975374 | http://purl.uniprot.org/core/author | "Li L."xsd:string |
| http://purl.uniprot.org/citations/23975374 | http://purl.uniprot.org/core/author | "Li M."xsd:string |
| http://purl.uniprot.org/citations/23975374 | http://purl.uniprot.org/core/author | "Li P."xsd:string |
| http://purl.uniprot.org/citations/23975374 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/23975374 | http://purl.uniprot.org/core/author | "Zhao G."xsd:string |
| http://purl.uniprot.org/citations/23975374 | http://purl.uniprot.org/core/author | "Zhang R."xsd:string |
| http://purl.uniprot.org/citations/23975374 | http://purl.uniprot.org/core/author | "Zang W."xsd:string |
| http://purl.uniprot.org/citations/23975374 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/23975374 | http://purl.uniprot.org/core/name | "Tumour Biol"xsd:string |
| http://purl.uniprot.org/citations/23975374 | http://purl.uniprot.org/core/pages | "837-844"xsd:string |
| http://purl.uniprot.org/citations/23975374 | http://purl.uniprot.org/core/title | "MiR-148a regulates the growth and apoptosis in pancreatic cancer by targeting CCKBR and Bcl-2."xsd:string |
| http://purl.uniprot.org/citations/23975374 | http://purl.uniprot.org/core/volume | "35"xsd:string |
| http://purl.uniprot.org/citations/23975374 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23975374 |
| http://purl.uniprot.org/citations/23975374 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23975374 |
| http://purl.uniprot.org/uniprot/#_A0A1L4AQQ4-mappedCitation-23975374 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23975374 |
| http://purl.uniprot.org/uniprot/#_E9PIC8-mappedCitation-23975374 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23975374 |
| http://purl.uniprot.org/uniprot/#_P10415-mappedCitation-23975374 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23975374 |
| http://purl.uniprot.org/uniprot/#_A0A1L4AQQ5-mappedCitation-23975374 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23975374 |
| http://purl.uniprot.org/uniprot/#_A0A1L4AQQ8-mappedCitation-23975374 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23975374 |
| http://purl.uniprot.org/uniprot/#_A0A1L4AQR6-mappedCitation-23975374 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23975374 |