| http://purl.uniprot.org/citations/23975425 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23975425 | http://www.w3.org/2000/01/rdf-schema#comment | "N-cadherin and HER2/neu were found to be co-expressed in invasive breast carcinomas. To test the contribution of N-cadherin and HER2 in mammary tumor metastasis, we targeted N-cadherin expression in the mammary epithelium of the MMTV-Neu mouse. In the context of ErbB2/Neu, N-cadherin stimulated carcinoma cell invasion, proliferation and metastasis. N-cadherin caused fibroblast growth factor receptor (FGFR) upmodulation, resulting in epithelial-to-mesenchymal transition (EMT) and stem/progenitor like properties, involving Snail and Slug upregulation, mammosphere formation and aldehyde dehydrogenase activity. N-cadherin potentiation of the FGFR stimulated extracellular signal regulated kinase (ERK) and protein kinase B (AKT) phosphorylation resulting in differential effects on metastasis. Although ERK inhibition suppressed cyclin D1 expression, cell proliferation and stem/progenitor cell properties, it did not affect invasion or EMT. Conversely, AKT inhibition suppressed invasion through Akt 2 attenuation, and EMT through Snail inhibition, but had no effect on cyclin D1 expression, cell proliferation or mammosphere formation. These findings suggest N-cadherin/FGFR has a pivotal role in promoting metastasis through differential regulation of ERK and AKT, and underscore the potential for targeting the FGFR in advanced ErbB2-amplified breast tumors."xsd:string |
| http://purl.uniprot.org/citations/23975425 | http://purl.org/dc/terms/identifier | "doi:10.1038/onc.2013.310"xsd:string |
| http://purl.uniprot.org/citations/23975425 | http://purl.uniprot.org/core/author | "Kim S."xsd:string |
| http://purl.uniprot.org/citations/23975425 | http://purl.uniprot.org/core/author | "Qian X."xsd:string |
| http://purl.uniprot.org/citations/23975425 | http://purl.uniprot.org/core/author | "Yao J."xsd:string |
| http://purl.uniprot.org/citations/23975425 | http://purl.uniprot.org/core/author | "Phillips G.R."xsd:string |
| http://purl.uniprot.org/citations/23975425 | http://purl.uniprot.org/core/author | "Agiostratidou G."xsd:string |
| http://purl.uniprot.org/citations/23975425 | http://purl.uniprot.org/core/author | "Suyama K."xsd:string |
| http://purl.uniprot.org/citations/23975425 | http://purl.uniprot.org/core/author | "Norton L."xsd:string |
| http://purl.uniprot.org/citations/23975425 | http://purl.uniprot.org/core/author | "Hulit J."xsd:string |
| http://purl.uniprot.org/citations/23975425 | http://purl.uniprot.org/core/author | "Hazan R.B."xsd:string |
| http://purl.uniprot.org/citations/23975425 | http://purl.uniprot.org/core/author | "McDaid H.M."xsd:string |
| http://purl.uniprot.org/citations/23975425 | http://purl.uniprot.org/core/author | "Nagi C."xsd:string |
| http://purl.uniprot.org/citations/23975425 | http://purl.uniprot.org/core/author | "Anzovino A."xsd:string |
| http://purl.uniprot.org/citations/23975425 | http://purl.uniprot.org/core/author | "Chandiramani N."xsd:string |
| http://purl.uniprot.org/citations/23975425 | http://purl.uniprot.org/core/author | "Cohen H.W."xsd:string |
| http://purl.uniprot.org/citations/23975425 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/23975425 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/23975425 | http://purl.uniprot.org/core/pages | "3411-3421"xsd:string |
| http://purl.uniprot.org/citations/23975425 | http://purl.uniprot.org/core/title | "N-cadherin/FGFR promotes metastasis through epithelial-to-mesenchymal transition and stem/progenitor cell-like properties."xsd:string |
| http://purl.uniprot.org/citations/23975425 | http://purl.uniprot.org/core/volume | "33"xsd:string |
| http://purl.uniprot.org/citations/23975425 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23975425 |
| http://purl.uniprot.org/citations/23975425 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23975425 |
| http://purl.uniprot.org/uniprot/#_D3YYT0-mappedCitation-23975425 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23975425 |