| http://purl.uniprot.org/citations/23977341 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23977341 | http://www.w3.org/2000/01/rdf-schema#comment | "Without exposure to any DNA-damaging agents, non-dividing eukaryotic cells carry endogenous DNA double-strand breaks (EDSBs), or Replication-Independent (RIND)-EDSBs. In human cells, RIND-EDSBs are enriched in the methylated heterochromatic areas of the genome and are repaired by an ATM-dependent non-homologous end-joining pathway (NHEJ). Here, we showed that Saccharomyces cerevisiae similarly possess RIND-EDSBs. Various levels of EDSBs were detected during different phases of the cell cycle, including G0. Using a collection of mutant yeast strains, we investigated various DNA metabolic and DNA repair pathways that might be involved in the maintenance of RIND-EDSB levels. We found that the RIND-EDSB levels increased significantly in yeast strains lacking proteins involved in NHEJ DNA repair and in suppression of heterochromatin formation. RIND-EDSB levels were also upregulated when genes encoding histone deacetylase, endonucleases, topoisomerase, and DNA repair regulators were deleted. In contrast, RIND-EDSB levels were downregulated in the mutants that lack chromatin-condensing proteins, such as the high-mobility group box proteins, and Sir2. Likewise, RIND-EDSB levels were also decreased in human cells lacking HMGB1. Therefore, we conclude that the genomic levels of RIND-EDSBs are evolutionally conserved, dynamically regulated, and may be influenced by genome topology, chromatin structure, and the efficiency of DNA repair systems."xsd:string |
| http://purl.uniprot.org/citations/23977341 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0072706"xsd:string |
| http://purl.uniprot.org/citations/23977341 | http://purl.uniprot.org/core/author | "Matangkasombut O."xsd:string |
| http://purl.uniprot.org/citations/23977341 | http://purl.uniprot.org/core/author | "Mutirangura A."xsd:string |
| http://purl.uniprot.org/citations/23977341 | http://purl.uniprot.org/core/author | "Jirawatnotai S."xsd:string |
| http://purl.uniprot.org/citations/23977341 | http://purl.uniprot.org/core/author | "Rattanatanyong P."xsd:string |
| http://purl.uniprot.org/citations/23977341 | http://purl.uniprot.org/core/author | "Thongnak A."xsd:string |
| http://purl.uniprot.org/citations/23977341 | http://purl.uniprot.org/core/author | "Thongsroy J."xsd:string |
| http://purl.uniprot.org/citations/23977341 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23977341 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/23977341 | http://purl.uniprot.org/core/pages | "e72706"xsd:string |
| http://purl.uniprot.org/citations/23977341 | http://purl.uniprot.org/core/title | "Replication-independent endogenous DNA double-strand breaks in Saccharomyces cerevisiae model."xsd:string |
| http://purl.uniprot.org/citations/23977341 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/23977341 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23977341 |
| http://purl.uniprot.org/citations/23977341 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23977341 |
| http://purl.uniprot.org/uniprot/#_P13099-mappedCitation-23977341 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23977341 |
| http://purl.uniprot.org/uniprot/#_Q03435-mappedCitation-23977341 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23977341 |
| http://purl.uniprot.org/uniprot/#_P46946-mappedCitation-23977341 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23977341 |
| http://purl.uniprot.org/uniprot/#_P06700-mappedCitation-23977341 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23977341 |
| http://purl.uniprot.org/uniprot/#_P11632-mappedCitation-23977341 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23977341 |
| http://purl.uniprot.org/uniprot/#_P11633-mappedCitation-23977341 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23977341 |
| http://purl.uniprot.org/uniprot/#_P26793-mappedCitation-23977341 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23977341 |
| http://purl.uniprot.org/uniprot/#_Q02486-mappedCitation-23977341 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23977341 |
| http://purl.uniprot.org/uniprot/#_Q03973-mappedCitation-23977341 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23977341 |