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http://purl.uniprot.org/citations/23980171http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/23980171http://www.w3.org/2000/01/rdf-schema#comment"Robust cytotoxic CD8(+) T-cell response is important for immunity to intracellular pathogens. Here, we show that the transcription factor IFN Regulatory Factor 4 (IRF4) is crucial for the protective CD8(+) T-cell response to the intracellular bacterium Listeria monocytogenes. IRF4-deficient (Irf4(-/-)) mice could not clear L. monocytogenes infection and generated decreased numbers of L. monocytogenes-specific CD8(+) T cells with impaired effector phenotype and function. Transfer of wild-type CD8(+) T cells into Irf4(-/-) mice improved bacterial clearance, suggesting an intrinsic defect of CD8(+) T cells in Irf4(-/-) mice. Following transfer into wild-type recipients, Irf4(-/-) CD8(+) T cells became activated and showed initial proliferation upon L. monocytogenes infection. However, these cells could not sustain proliferation, produced reduced amounts of IFN-γ and TNF-α, and failed to acquire cytotoxic function. Forced IRF4 expression in Irf4(-/-) CD8(+) T cells rescued the defect. During acute infection, Irf4(-/-) CD8(+) T cells demonstrated diminished expression of B lymphocyte-induced maturation protein-1 (Blimp-1), inhibitor of DNA binding (Id)2, and T-box expressed in T cells (T-bet), transcription factors programming effector-cell generation. IRF4 was essential for expression of Blimp-1, suggesting that altered regulation of Blimp-1 contributes to the defects of Irf4(-/-) CD8(+) T cells. Despite increased levels of B-cell lymphoma 6 (BCL-6), Eomesodermin, and Id3, Irf4(-/-) CD8(+) T cells showed impaired memory-cell formation, indicating additional functions for IRF4 in this process. As IRF4 governs B-cell and CD4(+) T-cell differentiation, the identification of its decisive role in peripheral CD8(+) T-cell differentiation, suggests a common regulatory function for IRF4 in adaptive lymphocytes fate decision."xsd:string
http://purl.uniprot.org/citations/23980171http://purl.org/dc/terms/identifier"doi:10.1073/pnas.1309378110"xsd:string
http://purl.uniprot.org/citations/23980171http://purl.uniprot.org/core/author"Klein M."xsd:string
http://purl.uniprot.org/citations/23980171http://purl.uniprot.org/core/author"Huber M."xsd:string
http://purl.uniprot.org/citations/23980171http://purl.uniprot.org/core/author"Raifer H."xsd:string
http://purl.uniprot.org/citations/23980171http://purl.uniprot.org/core/author"Lang P.A."xsd:string
http://purl.uniprot.org/citations/23980171http://purl.uniprot.org/core/author"Schumacher V."xsd:string
http://purl.uniprot.org/citations/23980171http://purl.uniprot.org/core/author"Bopp T."xsd:string
http://purl.uniprot.org/citations/23980171http://purl.uniprot.org/core/author"Mittrucker H.W."xsd:string
http://purl.uniprot.org/citations/23980171http://purl.uniprot.org/core/author"Raczkowski F."xsd:string
http://purl.uniprot.org/citations/23980171http://purl.uniprot.org/core/author"Ritter J."xsd:string
http://purl.uniprot.org/citations/23980171http://purl.uniprot.org/core/author"Kesper D.A."xsd:string
http://purl.uniprot.org/citations/23980171http://purl.uniprot.org/core/author"Guralnik A."xsd:string
http://purl.uniprot.org/citations/23980171http://purl.uniprot.org/core/author"Harb H."xsd:string
http://purl.uniprot.org/citations/23980171http://purl.uniprot.org/core/author"Pfefferle P.I."xsd:string
http://purl.uniprot.org/citations/23980171http://purl.uniprot.org/core/author"Grusdat M."xsd:string
http://purl.uniprot.org/citations/23980171http://purl.uniprot.org/core/author"Heesch K."xsd:string
http://purl.uniprot.org/citations/23980171http://purl.uniprot.org/core/author"Hocker L."xsd:string
http://purl.uniprot.org/citations/23980171http://purl.uniprot.org/core/date"2013"xsd:gYear
http://purl.uniprot.org/citations/23980171http://purl.uniprot.org/core/name"Proc Natl Acad Sci U S A"xsd:string
http://purl.uniprot.org/citations/23980171http://purl.uniprot.org/core/pages"15019-15024"xsd:string
http://purl.uniprot.org/citations/23980171http://purl.uniprot.org/core/title"The transcription factor Interferon Regulatory Factor 4 is required for the generation of protective effector CD8+ T cells."xsd:string
http://purl.uniprot.org/citations/23980171http://purl.uniprot.org/core/volume"110"xsd:string
http://purl.uniprot.org/citations/23980171http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/23980171
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