| http://purl.uniprot.org/citations/23981271 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23981271 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23981271 | http://www.w3.org/2000/01/rdf-schema#comment | "BF-CT1, a 13 kDa protein isolated from Bungarus fasciatus snake venom through CM cellulose ion exchange chromatography at 0.02 M NaCl salt gradient showed cytotoxicity in in vitro and in vivo experimental models. In in vivo Ehrlich ascites carcinoma (EAC) induced BALB/c mice model, BF-CT1 treatment reduced EAC cell count significantly through apoptotic cell death pathway as evidenced by FACS analysis, increased caspase 3, 9 activity and altered pro, antiapoptotic protein expression. BF-CT1 treatment caused cell shrinkage, chromatin condensation and induced apoptosis through increased caspase 3, caspase 9 activity, PARP cleavage and down regulation of heat shock proteins in U937 leukemic cell line. Cytosolic cytochrome C production was increased after BF-CT1 treatment upon U937 cell line. BF-CT1 treated U937 cell showed cell cycle arrest at sub G1 phase through cyclin D and CDK down regulation with up regulation of p15 and p16. It also down regulated PI3K/AKT pathway and MAPkinase pathway and promoted apoptosis and regulated cell proliferation in U937 cells. BF-CT1 prevented angiogenesis in in vitro U937 cell line through decreased VEGF and TGF-β1 production."xsd:string |
| http://purl.uniprot.org/citations/23981271 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.toxicon.2013.08.052"xsd:string |
| http://purl.uniprot.org/citations/23981271 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.toxicon.2013.08.052"xsd:string |
| http://purl.uniprot.org/citations/23981271 | http://purl.uniprot.org/core/author | "Bhattacharya S."xsd:string |
| http://purl.uniprot.org/citations/23981271 | http://purl.uniprot.org/core/author | "Bhattacharya S."xsd:string |
| http://purl.uniprot.org/citations/23981271 | http://purl.uniprot.org/core/author | "Biswas A."xsd:string |
| http://purl.uniprot.org/citations/23981271 | http://purl.uniprot.org/core/author | "Biswas A."xsd:string |
| http://purl.uniprot.org/citations/23981271 | http://purl.uniprot.org/core/author | "Gomes A."xsd:string |
| http://purl.uniprot.org/citations/23981271 | http://purl.uniprot.org/core/author | "Gomes A."xsd:string |
| http://purl.uniprot.org/citations/23981271 | http://purl.uniprot.org/core/author | "Das T."xsd:string |
| http://purl.uniprot.org/citations/23981271 | http://purl.uniprot.org/core/author | "Das T."xsd:string |
| http://purl.uniprot.org/citations/23981271 | http://purl.uniprot.org/core/author | "Gomes A.'"xsd:string |
| http://purl.uniprot.org/citations/23981271 | http://purl.uniprot.org/core/author | "Gomes A.'"xsd:string |
| http://purl.uniprot.org/citations/23981271 | http://purl.uniprot.org/core/author | "Dungdung S.R."xsd:string |
| http://purl.uniprot.org/citations/23981271 | http://purl.uniprot.org/core/author | "Dungdung S.R."xsd:string |
| http://purl.uniprot.org/citations/23981271 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23981271 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23981271 | http://purl.uniprot.org/core/name | "Toxicon"xsd:string |
| http://purl.uniprot.org/citations/23981271 | http://purl.uniprot.org/core/name | "Toxicon"xsd:string |
| http://purl.uniprot.org/citations/23981271 | http://purl.uniprot.org/core/pages | "138-150"xsd:string |
| http://purl.uniprot.org/citations/23981271 | http://purl.uniprot.org/core/pages | "138-150"xsd:string |
| http://purl.uniprot.org/citations/23981271 | http://purl.uniprot.org/core/title | "A cytotoxic protein (BF-CT1) purified from Bungarus fasciatus venom acts through apoptosis, modulation of PI3K/AKT, MAPKinase pathway and cell cycle regulation."xsd:string |
| http://purl.uniprot.org/citations/23981271 | http://purl.uniprot.org/core/title | "A cytotoxic protein (BF-CT1) purified from Bungarus fasciatus venom acts through apoptosis, modulation of PI3K/AKT, MAPKinase pathway and cell cycle regulation."xsd:string |