| http://purl.uniprot.org/citations/23982142 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23982142 | http://www.w3.org/2000/01/rdf-schema#comment | "Although thyroid-stimulating hormone (TSH) is known to be a major regulator of thyroid hormone biosynthesis and thyroid growth, insulin-like growth factor 1 (IGF-1) is required for mediating thyrocyte growth in concert with TSH in vitro. We generated mice with thyrocyte-selective ablation of IGF-1 receptor (TIGF1RKO) to explore the role of IGF-1 receptor signaling on thyroid function and growth. In 5-wk-old TIGF1RKO mice, serum thyroxine (T4) concentrations were decreased by 30% in concert with a 43% down-regulation of the monocarboxylate transporter 8 (MCT8), which is involved in T4 secretion. Despite a 3.5-fold increase in circulating concentrations of TSH, thyroid architecture and size were normal. Furthermore, thyrocyte area was increased by 40% in WT thyroids after 10 d TSH injection, but this effect was absent in TSH-injected TIGF1RKO mice. WT mice treated with methimazole and sodium perchlorate for 2 or 6 wk exhibited pronounced goiter development (2.0 and 5.4-fold, respectively), but in TIGF1RKO mice, goiter development was completely abrogated. These data reveal an essential role for IGF-1 receptor signaling in the regulation of thyroid function and TSH-stimulated goitrogenesis."xsd:string |
| http://purl.uniprot.org/citations/23982142 | http://purl.org/dc/terms/identifier | "doi:10.1096/fj.13-231381"xsd:string |
| http://purl.uniprot.org/citations/23982142 | http://purl.uniprot.org/core/author | "Kang H."xsd:string |
| http://purl.uniprot.org/citations/23982142 | http://purl.uniprot.org/core/author | "Kim J."xsd:string |
| http://purl.uniprot.org/citations/23982142 | http://purl.uniprot.org/core/author | "Lee I.K."xsd:string |
| http://purl.uniprot.org/citations/23982142 | http://purl.uniprot.org/core/author | "Lee S.H."xsd:string |
| http://purl.uniprot.org/citations/23982142 | http://purl.uniprot.org/core/author | "Ahn J."xsd:string |
| http://purl.uniprot.org/citations/23982142 | http://purl.uniprot.org/core/author | "Shong M."xsd:string |
| http://purl.uniprot.org/citations/23982142 | http://purl.uniprot.org/core/author | "Park W.J."xsd:string |
| http://purl.uniprot.org/citations/23982142 | http://purl.uniprot.org/core/author | "Offermanns S."xsd:string |
| http://purl.uniprot.org/citations/23982142 | http://purl.uniprot.org/core/author | "Jo D."xsd:string |
| http://purl.uniprot.org/citations/23982142 | http://purl.uniprot.org/core/author | "Lee T.J."xsd:string |
| http://purl.uniprot.org/citations/23982142 | http://purl.uniprot.org/core/author | "Ahn H.Y."xsd:string |
| http://purl.uniprot.org/citations/23982142 | http://purl.uniprot.org/core/author | "Jo Y.S."xsd:string |
| http://purl.uniprot.org/citations/23982142 | http://purl.uniprot.org/core/author | "Abel E.D."xsd:string |
| http://purl.uniprot.org/citations/23982142 | http://purl.uniprot.org/core/author | "Cho B.Y."xsd:string |
| http://purl.uniprot.org/citations/23982142 | http://purl.uniprot.org/core/author | "Ock S."xsd:string |
| http://purl.uniprot.org/citations/23982142 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23982142 | http://purl.uniprot.org/core/name | "FASEB J"xsd:string |
| http://purl.uniprot.org/citations/23982142 | http://purl.uniprot.org/core/pages | "4899-4908"xsd:string |
| http://purl.uniprot.org/citations/23982142 | http://purl.uniprot.org/core/title | "IGF-1 receptor deficiency in thyrocytes impairs thyroid hormone secretion and completely inhibits TSH-stimulated goiter."xsd:string |
| http://purl.uniprot.org/citations/23982142 | http://purl.uniprot.org/core/volume | "27"xsd:string |
| http://purl.uniprot.org/citations/23982142 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23982142 |
| http://purl.uniprot.org/citations/23982142 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23982142 |