| http://purl.uniprot.org/citations/23982744 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23982744 | http://www.w3.org/2000/01/rdf-schema#comment | "The role of Toll-like receptor 4 (TLR4) in the activation of innate immunity has been extensively studied in the past several years. Here, we are the first to report that myeloid-related protein 8 (MRP8), an endogenous TLR4 ligand, is involved in the epileptogenesis of mesial temporal lobe epilepsy (MTLE). We find that the expression of MRP8, TLR4, and interleukin 1-β (IL-1β) was upregulated in a MTLE model during both acute and chronic disease stages. We next investigated the possible roles played by astrocytes, which have been shown to be the major source of IL-1β during epilepsy. Stimulation via MRP8 led to the induction of IL-1β in astrocytes in vitro, accompanied by the activation of Nuclear Factor-κB, while knockdown of TLR4 or inhibition of NF-κB in astrocytes prevented this IL-1β induction. Thus, MRP8 may potentiate the perpetuation of MTLE by activating the NF-κB pathway in astrocytes, and could be a new target for anticonvulsant therapies."xsd:string |
| http://purl.uniprot.org/citations/23982744 | http://purl.org/dc/terms/identifier | "doi:10.1007/s12035-013-8522-7"xsd:string |
| http://purl.uniprot.org/citations/23982744 | http://purl.uniprot.org/core/author | "He F."xsd:string |
| http://purl.uniprot.org/citations/23982744 | http://purl.uniprot.org/core/author | "Kong H."xsd:string |
| http://purl.uniprot.org/citations/23982744 | http://purl.uniprot.org/core/author | "Deng X."xsd:string |
| http://purl.uniprot.org/citations/23982744 | http://purl.uniprot.org/core/author | "Peng J."xsd:string |
| http://purl.uniprot.org/citations/23982744 | http://purl.uniprot.org/core/author | "Ma Y."xsd:string |
| http://purl.uniprot.org/citations/23982744 | http://purl.uniprot.org/core/author | "Xiang Q."xsd:string |
| http://purl.uniprot.org/citations/23982744 | http://purl.uniprot.org/core/author | "Zhang C."xsd:string |
| http://purl.uniprot.org/citations/23982744 | http://purl.uniprot.org/core/author | "Yang L."xsd:string |
| http://purl.uniprot.org/citations/23982744 | http://purl.uniprot.org/core/author | "Wu L."xsd:string |
| http://purl.uniprot.org/citations/23982744 | http://purl.uniprot.org/core/author | "Yin F."xsd:string |
| http://purl.uniprot.org/citations/23982744 | http://purl.uniprot.org/core/author | "Gan N."xsd:string |
| http://purl.uniprot.org/citations/23982744 | http://purl.uniprot.org/core/author | "Omran A."xsd:string |
| http://purl.uniprot.org/citations/23982744 | http://purl.uniprot.org/core/author | "Ashhab M.U."xsd:string |
| http://purl.uniprot.org/citations/23982744 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/23982744 | http://purl.uniprot.org/core/name | "Mol Neurobiol"xsd:string |
| http://purl.uniprot.org/citations/23982744 | http://purl.uniprot.org/core/pages | "337-351"xsd:string |
| http://purl.uniprot.org/citations/23982744 | http://purl.uniprot.org/core/title | "Myoloid-related protein 8, an endogenous ligand of Toll-like receptor 4, is involved in epileptogenesis of mesial temporal lobe epilepsy via activation of the nuclear factor-kappaB pathway in astrocytes."xsd:string |
| http://purl.uniprot.org/citations/23982744 | http://purl.uniprot.org/core/volume | "49"xsd:string |
| http://purl.uniprot.org/citations/23982744 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23982744 |
| http://purl.uniprot.org/citations/23982744 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23982744 |
| http://purl.uniprot.org/uniprot/#_A6J6Q3-mappedCitation-23982744 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23982744 |
| http://purl.uniprot.org/uniprot/#_A6HVY5-mappedCitation-23982744 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23982744 |