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| http://purl.uniprot.org/citations/23986862 | http://www.w3.org/2000/01/rdf-schema#comment | "Chromatin assembly involves the combined action of ATP-dependent motor proteins and histone chaperones. Because motor proteins in chromatin assembly also function as chromatin remodeling factors, we investigated the relationship between ATP-driven chromatin assembly and chromatin remodeling in the generation of periodic nucleosome arrays. We found that chromatin remodeling-defective Chd1 motor proteins are able to catalyze ATP-dependent chromatin assembly. The resulting nucleosomes are not, however, spaced in periodic arrays. Wild-type Chd1, but not chromatin remodeling-defective Chd1, can catalyze the conversion of randomly-distributed nucleosomes into periodic arrays. These results reveal a functional distinction between ATP-dependent nucleosome assembly and chromatin remodeling, and suggest a model for chromatin assembly in which randomly-distributed nucleosomes are formed by the nucleosome assembly function of Chd1, and then regularly-spaced nucleosome arrays are generated by the chromatin remodeling activity of Chd1. These findings uncover an unforeseen level of specificity in the role of motor proteins in chromatin assembly. DOI:http://dx.doi.org/10.7554/eLife.00863.001."xsd:string |
| http://purl.uniprot.org/citations/23986862 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.00863"xsd:string |
| http://purl.uniprot.org/citations/23986862 | http://purl.uniprot.org/core/author | "Patel A."xsd:string |
| http://purl.uniprot.org/citations/23986862 | http://purl.uniprot.org/core/author | "Bowman G.D."xsd:string |
| http://purl.uniprot.org/citations/23986862 | http://purl.uniprot.org/core/author | "Kadonaga J.T."xsd:string |
| http://purl.uniprot.org/citations/23986862 | http://purl.uniprot.org/core/author | "Torigoe S.E."xsd:string |
| http://purl.uniprot.org/citations/23986862 | http://purl.uniprot.org/core/author | "Khuong M.T."xsd:string |
| http://purl.uniprot.org/citations/23986862 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
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| http://purl.uniprot.org/citations/23986862 | http://purl.uniprot.org/core/pages | "e00863"xsd:string |
| http://purl.uniprot.org/citations/23986862 | http://purl.uniprot.org/core/title | "ATP-dependent chromatin assembly is functionally distinct from chromatin remodeling."xsd:string |
| http://purl.uniprot.org/citations/23986862 | http://purl.uniprot.org/core/volume | "2"xsd:string |
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