| http://purl.uniprot.org/citations/23991225 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23991225 | http://www.w3.org/2000/01/rdf-schema#comment | "Our lab has previously shown in a mouse model that normalization of a low HDL level achieves atherosclerotic plaque regression. This included the shift from a pro ("M1") to an anti-inflammatory ("M2") phenotypic state of plaque macrophages. Whether HDL can directly cause this phenotypic change and, if so, what the signaling mechanism is, were explored in the present studies. Murine primary macrophages treated with HDL showed increased gene expression for the M2 markers Arginase-1 (Arg-1) and Fizz-1, which are classically induced by IL-4. HDL was able to potentiate the IL-4-induced changes in Arg-1, and tended to do the same for Fizz-1, while suppressing the expression of inflammatory genes in response to IFNγ. The effects of either IL-4 or HDL were suppressed when macrophages were from STAT6(-/-) mice, but inhibitor studies suggested differential utilization of JAK isoforms by IL-4 and HDL to activate STAT6 by phosphorylation. Overall, our results describe a new function of HDL, namely its ability to directly enrich macrophages in markers of the M2, anti-inflammatory, state in a process requiring STAT6."xsd:string |
| http://purl.uniprot.org/citations/23991225 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0074676"xsd:string |
| http://purl.uniprot.org/citations/23991225 | http://purl.uniprot.org/core/author | "Fisher E.A."xsd:string |
| http://purl.uniprot.org/citations/23991225 | http://purl.uniprot.org/core/author | "Sanson M."xsd:string |
| http://purl.uniprot.org/citations/23991225 | http://purl.uniprot.org/core/author | "Distel E."xsd:string |
| http://purl.uniprot.org/citations/23991225 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23991225 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/23991225 | http://purl.uniprot.org/core/pages | "e74676"xsd:string |
| http://purl.uniprot.org/citations/23991225 | http://purl.uniprot.org/core/title | "HDL induces the expression of the M2 macrophage markers arginase 1 and Fizz-1 in a STAT6-dependent process."xsd:string |
| http://purl.uniprot.org/citations/23991225 | http://purl.uniprot.org/core/volume | "8"xsd:string |
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| http://purl.uniprot.org/uniprot/Q61176 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23991225 |