| http://purl.uniprot.org/citations/23994026 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23994026 | http://www.w3.org/2000/01/rdf-schema#comment | "Obesity is characterised by hyperleptinaemia and hypoadiponectinaemia and these metabolic abnormalities may contribute to the progression of several obesity-associated cancers including oesophageal adenocarcinoma (OAC). We have examined the effects of leptin and adiponectin on OE33 OAC cells. Leptin stimulated proliferation, invasion and migration and inhibited apoptosis in a STAT3-dependant manner. Leptin-stimulated MMP-2 secretion in a partly STAT3-dependent manner and MMP-9 secretion via a STAT3-independent pathway. Adiponectin inhibited leptin-induced proliferation, migration, invasion, MMP secretion and reduced the anti-apoptotic effects: these effects of adiponectin were ameliorated by both a non-specific tyrosine phosphatase inhibitor and a specific PTP1B inhibitor. Adiponectin reduced leptin-stimulated JAK2 activation and STAT3 transcriptional activity in a PTP1B-sensitive manner and adiponectin increased both PTP1B protein and activity. We conclude that adiponectin restrains leptin-induced signalling and pro-carcinogenic behaviour by inhibiting the early events in leptin-induced signal transduction by activating PTP1B. Relative adiponectin deficiency in obesity may contribute to the promotion of OAC."xsd:string |
| http://purl.uniprot.org/citations/23994026 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.mce.2013.08.013"xsd:string |
| http://purl.uniprot.org/citations/23994026 | http://purl.uniprot.org/core/author | "Garcia-Morales C."xsd:string |
| http://purl.uniprot.org/citations/23994026 | http://purl.uniprot.org/core/author | "Ogunwobi O.O."xsd:string |
| http://purl.uniprot.org/citations/23994026 | http://purl.uniprot.org/core/author | "Mutungi G."xsd:string |
| http://purl.uniprot.org/citations/23994026 | http://purl.uniprot.org/core/author | "Beales I.L.P."xsd:string |
| http://purl.uniprot.org/citations/23994026 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/23994026 | http://purl.uniprot.org/core/name | "Mol Cell Endocrinol"xsd:string |
| http://purl.uniprot.org/citations/23994026 | http://purl.uniprot.org/core/pages | "150-158"xsd:string |
| http://purl.uniprot.org/citations/23994026 | http://purl.uniprot.org/core/title | "Adiponectin inhibits leptin-induced oncogenic signalling in oesophageal cancer cells by activation of PTP1B."xsd:string |
| http://purl.uniprot.org/citations/23994026 | http://purl.uniprot.org/core/volume | "382"xsd:string |
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