| http://purl.uniprot.org/citations/23994610 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23994610 | http://www.w3.org/2000/01/rdf-schema#comment | "Hepatocyte growth factor (HGF) and its receptor, Met, are key determinants of distinct developmental processes. Although HGF exerts cardio-protective effects in a number of cardiac pathologies, it remains unknown whether HGF/Met signaling is essential for myocardial development and/or physiological function in adulthood. We therefore investigated the requirement of HGF/Met signaling in cardiomyocyte for embryonic and postnatal heart development and function by conditional inactivation of the Met receptor in cardiomyocytes using the Cre-α-MHC mouse line (referred to as α-MHCMet-KO). Although α-MHCMet-KO mice showed normal heart development and were viable and fertile, by 6 months of age, males developed cardiomyocyte hypertrophy, associated with interstitial fibrosis. A significant upregulation in markers of myocardial damage, such as β-MHC and ANF, was also observed. By the age of 9 months, α-MHCMet-KO males displayed systolic cardiac dysfunction. Mechanistically, we provide evidence of a severe imbalance in the antioxidant defenses in α-MHCMet-KO hearts involving a reduced expression and activity of catalase and superoxide dismutase, with consequent reactive oxygen species accumulation. Similar anomalies were observed in females, although with a slower kinetics. We also found that Met signaling down-regulation leads to an increase in TGF-β production and a decrease in p38MAPK activation, which may contribute to phenotypic alterations displayed in α-MHCMet-KO mice. Consistently, we show that HGF acts through p38α to upregulate antioxidant enzymes in cardiomyocytes. Our results highlight that HGF/Met signaling in cardiomyocytes plays a physiological cardio-protective role in adult mice by acting as an endogenous regulator of heart function through oxidative stress control."xsd:string |
| http://purl.uniprot.org/citations/23994610 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbadis.2013.08.008"xsd:string |
| http://purl.uniprot.org/citations/23994610 | http://purl.uniprot.org/core/author | "Sanchez A."xsd:string |
| http://purl.uniprot.org/citations/23994610 | http://purl.uniprot.org/core/author | "Cano E."xsd:string |
| http://purl.uniprot.org/citations/23994610 | http://purl.uniprot.org/core/author | "Guerrero C."xsd:string |
| http://purl.uniprot.org/citations/23994610 | http://purl.uniprot.org/core/author | "Porras A."xsd:string |
| http://purl.uniprot.org/citations/23994610 | http://purl.uniprot.org/core/author | "Schneider M.D."xsd:string |
| http://purl.uniprot.org/citations/23994610 | http://purl.uniprot.org/core/author | "Maina F."xsd:string |
| http://purl.uniprot.org/citations/23994610 | http://purl.uniprot.org/core/author | "Carmona R."xsd:string |
| http://purl.uniprot.org/citations/23994610 | http://purl.uniprot.org/core/author | "Munoz-Chapuli R."xsd:string |
| http://purl.uniprot.org/citations/23994610 | http://purl.uniprot.org/core/author | "Lopez-Novoa J.M."xsd:string |
| http://purl.uniprot.org/citations/23994610 | http://purl.uniprot.org/core/author | "Gutierrez-Uzquiza A."xsd:string |
| http://purl.uniprot.org/citations/23994610 | http://purl.uniprot.org/core/author | "Bragado P."xsd:string |
| http://purl.uniprot.org/citations/23994610 | http://purl.uniprot.org/core/author | "Cruz-Gonzalez I."xsd:string |
| http://purl.uniprot.org/citations/23994610 | http://purl.uniprot.org/core/author | "Gonzalez-Nunez M."xsd:string |
| http://purl.uniprot.org/citations/23994610 | http://purl.uniprot.org/core/author | "Arechederra M."xsd:string |
| http://purl.uniprot.org/citations/23994610 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23994610 | http://purl.uniprot.org/core/name | "Biochim Biophys Acta"xsd:string |
| http://purl.uniprot.org/citations/23994610 | http://purl.uniprot.org/core/pages | "2204-2215"xsd:string |
| http://purl.uniprot.org/citations/23994610 | http://purl.uniprot.org/core/title | "Met signaling in cardiomyocytes is required for normal cardiac function in adult mice."xsd:string |
| http://purl.uniprot.org/citations/23994610 | http://purl.uniprot.org/core/volume | "1832"xsd:string |
| http://purl.uniprot.org/citations/23994610 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23994610 |
| http://purl.uniprot.org/citations/23994610 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23994610 |
| http://purl.uniprot.org/uniprot/Q08048#attribution-EF135E8BD24B723FDDA60F5B00B571B4 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23994610 |