DESCRIBE <http://purl.uniprot.org/citations/23999075>

Subject	Predicate	Object
http://purl.uniprot.org/citations/23999075	http://www.w3.org/1999/02/22-rdf-syntax-ns#type	http://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/23999075	http://www.w3.org/2000/01/rdf-schema#comment	" Background Neurotrophic signaling is an important factor in the survival of developing neurons, and the expression of neurotrophic receptors correlates with prognosis in neuroblastoma. Kinase D-interacting substrate of 220 kDa (Kidins220) associates with neurotrophic receptors and stabilizes them, but the expression and function of Kidins220 in neuroblastoma are unknown. Methods We study Kidins220 expression in human neuroblastoma cell lines and tumor samples by western blotting and microarray analyses. We determine the functional consequences of downregulation of Kidins220 for response of cell lines to oxidative stress, chemotherapeutic treatment, and neurotrophins using small interfering RNA silencing and by measuring cell survival, signaling, and migration. Results Kidins220 is expressed in all neuroblastoma tumors and cell lines studied. Downregulation of Kidins220 leads to attenuation of nerve growth factor (NGF)-induced, but not brain-derived neurotrophic factor (BDNF)-induced, MAPK signaling. However, downregulation of Kidins220 does not alter the response to chemotherapeutic drugs or oxidative stress or affect cellular motility. Conclusion Kidins220 is expressed in neuroblastoma tumors and stabilizes NGF-induced, but not BDNF-induced, survival signaling in neuroblastoma cell lines."xsd:string
http://purl.uniprot.org/citations/23999075	http://purl.org/dc/terms/identifier	"doi:10.1038/pr.2013.146"xsd:string
http://purl.uniprot.org/citations/23999075	http://purl.uniprot.org/core/author	"Rogers D.A."xsd:string
http://purl.uniprot.org/citations/23999075	http://purl.uniprot.org/core/author	"Schor N.F."xsd:string
http://purl.uniprot.org/citations/23999075	http://purl.uniprot.org/core/date	"2013"xsd:gYear
http://purl.uniprot.org/citations/23999075	http://purl.uniprot.org/core/name	"Pediatr Res"xsd:string
http://purl.uniprot.org/citations/23999075	http://purl.uniprot.org/core/pages	"517-524"xsd:string
http://purl.uniprot.org/citations/23999075	http://purl.uniprot.org/core/title	"Kidins220/ARMS is expressed in neuroblastoma tumors and stabilizes neurotrophic signaling in a human neuroblastoma cell line."xsd:string
http://purl.uniprot.org/citations/23999075	http://purl.uniprot.org/core/volume	"74"xsd:string
http://purl.uniprot.org/citations/23999075	http://www.w3.org/2004/02/skos/core#exactMatch	http://purl.uniprot.org/pubmed/23999075
http://purl.uniprot.org/citations/23999075	http://xmlns.com/foaf/0.1/primaryTopicOf	https://pubmed.ncbi.nlm.nih.gov/23999075
http://purl.uniprot.org/uniprot/#_A0A076N408-mappedCitation-23999075	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/23999075
http://purl.uniprot.org/uniprot/#_A0A076N8A7-mappedCitation-23999075	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/23999075
http://purl.uniprot.org/uniprot/#_A0A076NBC8-mappedCitation-23999075	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/23999075
http://purl.uniprot.org/uniprot/#_B4DGY1-mappedCitation-23999075	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/23999075
http://purl.uniprot.org/uniprot/#_B4DG84-mappedCitation-23999075	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/23999075
http://purl.uniprot.org/uniprot/#_B4DI12-mappedCitation-23999075	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/23999075
http://purl.uniprot.org/uniprot/#_B4DK94-mappedCitation-23999075	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/23999075
http://purl.uniprot.org/uniprot/#_G1UI41-mappedCitation-23999075	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/23999075
http://purl.uniprot.org/uniprot/#_Q7Z322-mappedCitation-23999075	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/23999075
http://purl.uniprot.org/uniprot/#_Q9ULH0-mappedCitation-23999075	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/23999075
http://purl.uniprot.org/uniprot/Q9ULH0	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/23999075
http://purl.uniprot.org/uniprot/A0A076N8A7	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/23999075
http://purl.uniprot.org/uniprot/B4DGY1	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/23999075