| http://purl.uniprot.org/citations/23999124 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23999124 | http://www.w3.org/2000/01/rdf-schema#comment | "Ras homolog enriched in striatum (Rhes), is a highly conserved small guanosine-5'-triphosphate (GTP) binding protein belonging to the Ras superfamily. Rhes is involved in the dopamine receptor-mediated signaling and behavior though adenylyl cyclase. The striatum-specific GTPase share a close homology with Dexras1, which regulates iron trafficking in the neurons when activated though the post-translational modification called s-nitrosylation by nitric oxide (NO). We report that Rhes physiologically interacted with Peripheral benzodiazepine receptor-associated protein7 and participated in iron uptake via divalent metal transporter 1 similar to Dexras1. Interestingly, Rhes is not S-nitrosylated by NO-treatment, however phosphorylated by protein kinase A at the site of serine-239. Two Rhes mutants - the phosphomimetic form (serine 239 to aspartic acid) and constitutively active form (alanine 173 to valine) - displayed an increase in iron uptake compared to the wild-type Rhes. These findings suggest that Rhes may play a crucial role in striatal iron homeostasis."xsd:string |
| http://purl.uniprot.org/citations/23999124 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuroscience.2013.08.043"xsd:string |
| http://purl.uniprot.org/citations/23999124 | http://purl.uniprot.org/core/author | "Chen Y."xsd:string |
| http://purl.uniprot.org/citations/23999124 | http://purl.uniprot.org/core/author | "Bang S."xsd:string |
| http://purl.uniprot.org/citations/23999124 | http://purl.uniprot.org/core/author | "Kim S.F."xsd:string |
| http://purl.uniprot.org/citations/23999124 | http://purl.uniprot.org/core/author | "Choi B.R."xsd:string |
| http://purl.uniprot.org/citations/23999124 | http://purl.uniprot.org/core/author | "Cheah J.H."xsd:string |
| http://purl.uniprot.org/citations/23999124 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23999124 | http://purl.uniprot.org/core/name | "Neuroscience"xsd:string |
| http://purl.uniprot.org/citations/23999124 | http://purl.uniprot.org/core/pages | "214-220"xsd:string |
| http://purl.uniprot.org/citations/23999124 | http://purl.uniprot.org/core/title | "PKA modulates iron trafficking in the striatum via small GTPase, Rhes."xsd:string |
| http://purl.uniprot.org/citations/23999124 | http://purl.uniprot.org/core/volume | "253"xsd:string |
| http://purl.uniprot.org/citations/23999124 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23999124 |
| http://purl.uniprot.org/citations/23999124 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23999124 |
| http://purl.uniprot.org/uniprot/#_Q96D21-mappedCitation-23999124 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23999124 |
| http://purl.uniprot.org/uniprot/Q96D21 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23999124 |