http://purl.uniprot.org/citations/24003139 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/24003139 | http://www.w3.org/2000/01/rdf-schema#comment | "The easy accessibility of energy-rich palatable food makes it difficult to resist food temptation. Drosophila larvae are surrounded by sugar-rich food most of their lives, raising the question of how these animals modulate food-seeking behaviors in tune with physiological needs. Here we describe a circuit mechanism defined by neurons expressing tdc2-Gal4 (a tyrosine decarboxylase 2 promoter-directed driver) that selectively drives a distinct foraging strategy in food-deprived larvae. Stimulation of this otherwise functionally latent circuit in tdc2-Gal4 neurons was sufficient to induce exuberant feeding of liquid food in fed animals, whereas targeted lesions in a small subset of tdc2-Gal4 neurons in the subesophageal ganglion blocked hunger-driven increases in the feeding response. Furthermore, regulation of feeding rate enhancement by tdc2-Gal4 neurons requires a novel signaling mechanism involving the VEGF2-like receptor, octopamine, and its receptor. Our findings provide fresh insight for the neurobiology and evolution of appetitive motivation."xsd:string |
http://purl.uniprot.org/citations/24003139 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1308816110"xsd:string |
http://purl.uniprot.org/citations/24003139 | http://purl.uniprot.org/core/author | "Shen P."xsd:string |
http://purl.uniprot.org/citations/24003139 | http://purl.uniprot.org/core/author | "Zhang T."xsd:string |
http://purl.uniprot.org/citations/24003139 | http://purl.uniprot.org/core/author | "Branch A."xsd:string |
http://purl.uniprot.org/citations/24003139 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
http://purl.uniprot.org/citations/24003139 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
http://purl.uniprot.org/citations/24003139 | http://purl.uniprot.org/core/pages | "15431-15436"xsd:string |
http://purl.uniprot.org/citations/24003139 | http://purl.uniprot.org/core/title | "Octopamine-mediated circuit mechanism underlying controlled appetite for palatable food in Drosophila."xsd:string |
http://purl.uniprot.org/citations/24003139 | http://purl.uniprot.org/core/volume | "110"xsd:string |
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