| http://purl.uniprot.org/citations/24005904 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24005904 | http://www.w3.org/2000/01/rdf-schema#comment | "Macrophages play a critical role in chronic inflammation and metabolic diseases. We identified a longer splice variant of ubiquitin specific protease (USP) 2-69 as a novel molecule that modulates pathways implicated in metabolic disorders. Expression levels of aP2/FABP4 and PAI-1/SERPINE1 genes were increased by 4- and 1.8-fold, respectively, after short hairpin RNA-mediated knockdown (KD) of the USP2 gene, and such expression was alleviated by overexpression of USP2-69 in human myeloid cell lines. Supernatants derived from USP2-KD cells induced IL6 (∼6-fold) and SAA3 (∼15-fold) in 3T3-L1 adipocytes to suggest the anti-inflammatory properties of USP2. In addition, we observed a 30% decrease in the number of macrophages in mesenteric adipose tissue derived from USP2-69 transgenic mice fed a high-fat diet for 14 wk compared with that in their C57BL/6 littermates (P<0.01), which was consistent with a ∼40% decrease in transcription of aP2 and PAI-1. The aP2 locus exhibited elevated chromatin accessibility (>2.1-fold), methylation of histone H3 lysine 4 (>4.5-fold), and acetylation of histone H4 (>2.5-fold) in USP2-KD cells. Transfection of isopeptidase-mutated USP2-69 did not alter chromatin conformation on the aP2 locus in USP2-KD cells. Our results suggest that USP2-69 suppresses meta-inflammatory molecules involved in the development of type-2 diabetes."xsd:string |
| http://purl.uniprot.org/citations/24005904 | http://purl.org/dc/terms/identifier | "doi:10.1096/fj.13-233528"xsd:string |
| http://purl.uniprot.org/citations/24005904 | http://purl.uniprot.org/core/author | "Miyamoto T."xsd:string |
| http://purl.uniprot.org/citations/24005904 | http://purl.uniprot.org/core/author | "Kitamura H."xsd:string |
| http://purl.uniprot.org/citations/24005904 | http://purl.uniprot.org/core/author | "Ito M."xsd:string |
| http://purl.uniprot.org/citations/24005904 | http://purl.uniprot.org/core/author | "Kimura S."xsd:string |
| http://purl.uniprot.org/citations/24005904 | http://purl.uniprot.org/core/author | "Ohara O."xsd:string |
| http://purl.uniprot.org/citations/24005904 | http://purl.uniprot.org/core/author | "Okamoto S."xsd:string |
| http://purl.uniprot.org/citations/24005904 | http://purl.uniprot.org/core/author | "Ishizuka M."xsd:string |
| http://purl.uniprot.org/citations/24005904 | http://purl.uniprot.org/core/author | "Hase K."xsd:string |
| http://purl.uniprot.org/citations/24005904 | http://purl.uniprot.org/core/author | "Naoe Y."xsd:string |
| http://purl.uniprot.org/citations/24005904 | http://purl.uniprot.org/core/author | "Shimamoto Y."xsd:string |
| http://purl.uniprot.org/citations/24005904 | http://purl.uniprot.org/core/author | "Kikuguchi C."xsd:string |
| http://purl.uniprot.org/citations/24005904 | http://purl.uniprot.org/core/author | "Miyoshi I."xsd:string |
| http://purl.uniprot.org/citations/24005904 | http://purl.uniprot.org/core/author | "Kanehira K."xsd:string |
| http://purl.uniprot.org/citations/24005904 | http://purl.uniprot.org/core/author | "Watarai H."xsd:string |
| http://purl.uniprot.org/citations/24005904 | http://purl.uniprot.org/core/author | "Okabe J."xsd:string |
| http://purl.uniprot.org/citations/24005904 | http://purl.uniprot.org/core/author | "Toda C."xsd:string |
| http://purl.uniprot.org/citations/24005904 | http://purl.uniprot.org/core/author | "El-Osta A."xsd:string |
| http://purl.uniprot.org/citations/24005904 | http://purl.uniprot.org/core/author | "Meek B."xsd:string |
| http://purl.uniprot.org/citations/24005904 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24005904 | http://purl.uniprot.org/core/name | "FASEB J"xsd:string |
| http://purl.uniprot.org/citations/24005904 | http://purl.uniprot.org/core/pages | "4940-4953"xsd:string |
| http://purl.uniprot.org/citations/24005904 | http://purl.uniprot.org/core/title | "Ubiquitin-specific protease 2-69 in macrophages potentially modulates metainflammation."xsd:string |