| http://purl.uniprot.org/citations/24006493 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24006493 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24006493 | http://www.w3.org/2000/01/rdf-schema#comment | "In humans, MOZART1 plays an essential role in mitotic spindle formation as a component of the γ-tubulin ring complex. We report that the fission yeast homologue of MOZART1, Mzt1/Tam4, is located at microtubule-organizing centers (MTOCs) and coimmunoprecipitates with γ-tubulin Gtb1 from cell extracts. We show that mzt1/tam4 is an essential gene in fission yeast, encoding a 64-amino acid peptide, depletion of which leads to aberrant microtubule structure, including malformed mitotic spindles and impaired interphase microtubule array. Mzt1/Tam4 depletion also causes cytokinesis defects, suggesting a role of the γ-tubulin complex in the regulation of cytokinesis. Yeast two-hybrid analysis shows that Mzt1/Tam4 forms a complex with Alp6, a fission yeast homologue of γ-tubulin complex protein 3 (GCP3). Biophysical methods demonstrate that there is a direct interaction between recombinant Mzt1/Tam4 and the N-terminal region of GCP3(Alp6). Together our results suggest that Mzt1/Tam4 contributes to the MTOC function through regulation of GCP3(Alp6)."xsd:string |
| http://purl.uniprot.org/citations/24006493 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e13-05-0253"xsd:string |
| http://purl.uniprot.org/citations/24006493 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e13-05-0253"xsd:string |
| http://purl.uniprot.org/citations/24006493 | http://purl.uniprot.org/core/author | "Tanaka K."xsd:string |
| http://purl.uniprot.org/citations/24006493 | http://purl.uniprot.org/core/author | "Tanaka K."xsd:string |
| http://purl.uniprot.org/citations/24006493 | http://purl.uniprot.org/core/author | "Bitton D.A."xsd:string |
| http://purl.uniprot.org/citations/24006493 | http://purl.uniprot.org/core/author | "Bitton D.A."xsd:string |
| http://purl.uniprot.org/citations/24006493 | http://purl.uniprot.org/core/author | "Goult B.T."xsd:string |
| http://purl.uniprot.org/citations/24006493 | http://purl.uniprot.org/core/author | "Goult B.T."xsd:string |
| http://purl.uniprot.org/citations/24006493 | http://purl.uniprot.org/core/author | "Miller C.J."xsd:string |
| http://purl.uniprot.org/citations/24006493 | http://purl.uniprot.org/core/author | "Miller C.J."xsd:string |
| http://purl.uniprot.org/citations/24006493 | http://purl.uniprot.org/core/author | "Dhani D.K."xsd:string |
| http://purl.uniprot.org/citations/24006493 | http://purl.uniprot.org/core/author | "Dhani D.K."xsd:string |
| http://purl.uniprot.org/citations/24006493 | http://purl.uniprot.org/core/author | "George G.M."xsd:string |
| http://purl.uniprot.org/citations/24006493 | http://purl.uniprot.org/core/author | "George G.M."xsd:string |
| http://purl.uniprot.org/citations/24006493 | http://purl.uniprot.org/core/author | "Rogerson D.T."xsd:string |
| http://purl.uniprot.org/citations/24006493 | http://purl.uniprot.org/core/author | "Rogerson D.T."xsd:string |
| http://purl.uniprot.org/citations/24006493 | http://purl.uniprot.org/core/author | "Schwabe J.W."xsd:string |
| http://purl.uniprot.org/citations/24006493 | http://purl.uniprot.org/core/author | "Schwabe J.W."xsd:string |
| http://purl.uniprot.org/citations/24006493 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24006493 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24006493 | http://purl.uniprot.org/core/name | "Mol. Biol. Cell"xsd:string |
| http://purl.uniprot.org/citations/24006493 | http://purl.uniprot.org/core/name | "Mol. Biol. Cell"xsd:string |