| http://purl.uniprot.org/citations/24012335 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24012335 | http://www.w3.org/2000/01/rdf-schema#comment | "Although Merlin/NF2 was discovered two decades ago as a tumor suppressor underlying Neurofibromatosis type II, its precise molecular mechanism remains poorly understood. Recent studies in Drosophila revealed a potential link between Merlin and the Hippo pathway by placing Merlin genetically upstream of the kinase Hpo/Mst. In contrast to the commonly depicted linear model of Merlin functioning through Hpo/Mst, here we show that in both Drosophila and mammals, Merlin promotes downstream Hippo signaling without activating the intrinsic kinase activity of Hpo/Mst. Instead, Merlin directly binds and recruits the effector kinase Wts/Lats to the plasma membrane. Membrane recruitment, in turn, promotes Wts phosphorylation by the Hpo-Sav kinase complex. We further show that disruption of the actin cytoskeleton promotes Merlin-Wts interactions, which implicates Merlin in actin-mediated regulation of Hippo signaling. Our findings elucidate an important molecular function of Merlin and highlight the plasma membrane as a critical subcellular compartment for Hippo signal transduction."xsd:string |
| http://purl.uniprot.org/citations/24012335 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2013.08.025"xsd:string |
| http://purl.uniprot.org/citations/24012335 | http://purl.uniprot.org/core/author | "Chen Q."xsd:string |
| http://purl.uniprot.org/citations/24012335 | http://purl.uniprot.org/core/author | "Pan D."xsd:string |
| http://purl.uniprot.org/citations/24012335 | http://purl.uniprot.org/core/author | "Zheng Y."xsd:string |
| http://purl.uniprot.org/citations/24012335 | http://purl.uniprot.org/core/author | "Yu J."xsd:string |
| http://purl.uniprot.org/citations/24012335 | http://purl.uniprot.org/core/author | "Zhang N."xsd:string |
| http://purl.uniprot.org/citations/24012335 | http://purl.uniprot.org/core/author | "Yin F."xsd:string |
| http://purl.uniprot.org/citations/24012335 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24012335 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/24012335 | http://purl.uniprot.org/core/pages | "1342-1355"xsd:string |
| http://purl.uniprot.org/citations/24012335 | http://purl.uniprot.org/core/title | "Spatial organization of Hippo signaling at the plasma membrane mediated by the tumor suppressor Merlin/NF2."xsd:string |
| http://purl.uniprot.org/citations/24012335 | http://purl.uniprot.org/core/volume | "154"xsd:string |
| http://purl.uniprot.org/citations/24012335 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24012335 |
| http://purl.uniprot.org/citations/24012335 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24012335 |
| http://purl.uniprot.org/uniprot/Q24564#attribution-CE672CF9A120D3F743F60BE6F8547A4B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24012335 |
| http://purl.uniprot.org/uniprot/Q24564#attribution-D75A8B5B84A1CAC1BE083641101F8C1C | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24012335 |
| http://purl.uniprot.org/uniprot/Q24564#attribution-F2D8E9CB856BE4D7C332E7EA8226D0A0 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24012335 |
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| http://purl.uniprot.org/uniprot/#_A0A0B4JDB7-mappedCitation-24012335 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24012335 |
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