| http://purl.uniprot.org/citations/24012369 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24012369 | http://www.w3.org/2000/01/rdf-schema#comment | "In adult skin, self-renewing, undifferentiated hair follicle stem cells (HF-SCs) reside within a specialized niche, where they spend prolonged times as a single layer of polarized, quiescent epithelial cells. When sufficient activating signals accumulate, HF-SCs become mobilized to fuel tissue regeneration and hair growth. Here, we show that architectural organization of the HF-SC niche by transcription factor LHX2 plays a critical role in HF-SC behavior. Using genome-wide chromatin and transcriptional profiling of HF-SCs in vivo, we show that LHX2 directly transactivates genes that orchestrate cytoskeletal dynamics and adhesion. Conditional ablation of LHX2 results in gross cellular disorganization and HF-SC polarization within the niche. LHX2 loss leads to a failure to maintain HF-SC quiescence and hair anchoring, as well as progressive transformation of the niche into a sebaceous gland. These findings suggest that niche organization underlies the requirement for LHX2 in hair follicle structure and function."xsd:string |
| http://purl.uniprot.org/citations/24012369 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.stem.2013.06.018"xsd:string |
| http://purl.uniprot.org/citations/24012369 | http://purl.uniprot.org/core/author | "Guo X."xsd:string |
| http://purl.uniprot.org/citations/24012369 | http://purl.uniprot.org/core/author | "Zheng D."xsd:string |
| http://purl.uniprot.org/citations/24012369 | http://purl.uniprot.org/core/author | "Fuchs E."xsd:string |
| http://purl.uniprot.org/citations/24012369 | http://purl.uniprot.org/core/author | "Folgueras A.R."xsd:string |
| http://purl.uniprot.org/citations/24012369 | http://purl.uniprot.org/core/author | "Pasolli H.A."xsd:string |
| http://purl.uniprot.org/citations/24012369 | http://purl.uniprot.org/core/author | "Stokes N."xsd:string |
| http://purl.uniprot.org/citations/24012369 | http://purl.uniprot.org/core/author | "Polak L."xsd:string |
| http://purl.uniprot.org/citations/24012369 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24012369 | http://purl.uniprot.org/core/name | "Cell Stem Cell"xsd:string |
| http://purl.uniprot.org/citations/24012369 | http://purl.uniprot.org/core/pages | "314-327"xsd:string |
| http://purl.uniprot.org/citations/24012369 | http://purl.uniprot.org/core/title | "Architectural niche organization by LHX2 is linked to hair follicle stem cell function."xsd:string |
| http://purl.uniprot.org/citations/24012369 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/24012369 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24012369 |
| http://purl.uniprot.org/citations/24012369 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24012369 |
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