| http://purl.uniprot.org/citations/24013218 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24013218 | http://www.w3.org/2000/01/rdf-schema#comment | "Autophagy is a cellular defense response to stress conditions, such as nutrient starvation. The type III phosphatidylinositol (PtdIns) 3-kinase, whose catalytic subunit is PIK3C3/VPS34, plays a critical role in intracellular membrane trafficking and autophagy induction. PIK3C3 forms multiple complexes and the ATG14-containing PIK3C3 is specifically involved in autophagy induction. Mechanistic target of rapamycin (MTOR) complex 1, MTORC1, is a key cellular nutrient sensor and integrator to stimulate anabolism and inhibit catabolism. Inactivation of TORC1 by nutrient starvation plays a critical role in autophagy induction. In this report we demonstrated that MTORC1 inactivation is critical for the activation of the autophagy-specific (ATG14-containing) PIK3C3 kinase, whereas it has no effect on ATG14-free PIK3C3 complexes. MTORC1 inhibits the PtdIns 3-kinase activity of ATG14-containing PIK3C3 by phosphorylating ATG14, which is required for PIK3C3 inhibition by MTORC1 both in vitro and in vivo. Our data suggest a mechanistic link between amino acid starvation and autophagy induction via the direct activation of the autophagy-specific PIK3C3 kinase."xsd:string |
| http://purl.uniprot.org/citations/24013218 | http://purl.org/dc/terms/identifier | "doi:10.4161/auto.26058"xsd:string |
| http://purl.uniprot.org/citations/24013218 | http://purl.uniprot.org/core/author | "Guan K.L."xsd:string |
| http://purl.uniprot.org/citations/24013218 | http://purl.uniprot.org/core/author | "Russell R.C."xsd:string |
| http://purl.uniprot.org/citations/24013218 | http://purl.uniprot.org/core/author | "Yuan H.X."xsd:string |
| http://purl.uniprot.org/citations/24013218 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24013218 | http://purl.uniprot.org/core/name | "Autophagy"xsd:string |
| http://purl.uniprot.org/citations/24013218 | http://purl.uniprot.org/core/pages | "1983-1995"xsd:string |
| http://purl.uniprot.org/citations/24013218 | http://purl.uniprot.org/core/title | "Regulation of PIK3C3/VPS34 complexes by MTOR in nutrient stress-induced autophagy."xsd:string |
| http://purl.uniprot.org/citations/24013218 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/24013218 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24013218 |
| http://purl.uniprot.org/citations/24013218 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24013218 |
| http://purl.uniprot.org/uniprot/#_A8MYT4-mappedCitation-24013218 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24013218 |
| http://purl.uniprot.org/uniprot/#_B4DPV9-mappedCitation-24013218 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24013218 |
| http://purl.uniprot.org/uniprot/#_Q8NEB9-mappedCitation-24013218 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24013218 |
| http://purl.uniprot.org/uniprot/Q8NEB9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24013218 |
| http://purl.uniprot.org/uniprot/A8MYT4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24013218 |
| http://purl.uniprot.org/uniprot/B4DPV9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24013218 |