| http://purl.uniprot.org/citations/24013230 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24013230 | http://www.w3.org/2000/01/rdf-schema#comment | "Loss of the DNA mismatch repair (MMR) protein MSH3 leads to the development of a variety of tumors in mice without significantly affecting survival rates, suggesting a modulating role for the MutSβ (MSH2-MSH3) complex in late-onset tumorigenesis. To better study the role of MSH3 in tumor progression, we crossed Msh3(-/-) mice onto a tumor predisposing p53-deficient background. Survival of Msh3/p53 mice was not reduced compared with p53 single mutant mice; however, the tumor spectrum changed significantly from lymphoma to sarcoma, indicating MSH3 as a potent modulator of p53-driven tumorigenesis. Interestingly, Msh3(-/-) mouse embryonic fibroblasts displayed increased chromatid breaks and persistence of γH2AX foci following ionizing radiation, indicating a defect in DNA double-strand break repair (DSBR). Msh3/p53 tumors showed increased loss of heterozygosity, elevated genome-wide copy-number variation and a moderate microsatellite instability phenotype compared with Msh2/p53 tumors, revealing that MSH2-MSH3 suppresses tumorigenesis by maintaining chromosomal stability. Our results show that the MSH2-MSH3 complex is important for the suppression of late-onset tumors due to its roles in DNA DSBR as well as in DNA MMR. Further, they demonstrate that MSH2-MSH3 suppresses chromosomal instability and modulates the tumor spectrum in p53-deficient tumorigenesis and possibly has a role in other chromosomally unstable tumors as well."xsd:string |
| http://purl.uniprot.org/citations/24013230 | http://purl.org/dc/terms/identifier | "doi:10.1038/onc.2013.365"xsd:string |
| http://purl.uniprot.org/citations/24013230 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/24013230 | http://purl.uniprot.org/core/author | "Zhang W."xsd:string |
| http://purl.uniprot.org/citations/24013230 | http://purl.uniprot.org/core/author | "Smith C."xsd:string |
| http://purl.uniprot.org/citations/24013230 | http://purl.uniprot.org/core/author | "Bergman A."xsd:string |
| http://purl.uniprot.org/citations/24013230 | http://purl.uniprot.org/core/author | "Scharff M.D."xsd:string |
| http://purl.uniprot.org/citations/24013230 | http://purl.uniprot.org/core/author | "Jin B."xsd:string |
| http://purl.uniprot.org/citations/24013230 | http://purl.uniprot.org/core/author | "Edwards Y."xsd:string |
| http://purl.uniprot.org/citations/24013230 | http://purl.uniprot.org/core/author | "Chahwan R."xsd:string |
| http://purl.uniprot.org/citations/24013230 | http://purl.uniprot.org/core/author | "Edelmann W."xsd:string |
| http://purl.uniprot.org/citations/24013230 | http://purl.uniprot.org/core/author | "Schaetzlein S."xsd:string |
| http://purl.uniprot.org/citations/24013230 | http://purl.uniprot.org/core/author | "van Oers J.M."xsd:string |
| http://purl.uniprot.org/citations/24013230 | http://purl.uniprot.org/core/author | "Pechuan X."xsd:string |
| http://purl.uniprot.org/citations/24013230 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24013230 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/24013230 | http://purl.uniprot.org/core/pages | "3939-3946"xsd:string |
| http://purl.uniprot.org/citations/24013230 | http://purl.uniprot.org/core/title | "The MutSbeta complex is a modulator of p53-driven tumorigenesis through its functions in both DNA double-strand break repair and mismatch repair."xsd:string |
| http://purl.uniprot.org/citations/24013230 | http://purl.uniprot.org/core/volume | "33"xsd:string |
| http://purl.uniprot.org/citations/24013230 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24013230 |
| http://purl.uniprot.org/citations/24013230 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24013230 |
| http://purl.uniprot.org/uniprot/#_A0A087WQ16-mappedCitation-24013230 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24013230 |
| http://purl.uniprot.org/uniprot/#_A0A087WP43-mappedCitation-24013230 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24013230 |
| http://purl.uniprot.org/uniprot/#_A0A087WP45-mappedCitation-24013230 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24013230 |