| http://purl.uniprot.org/citations/24018150 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24018150 | http://www.w3.org/2000/01/rdf-schema#comment | "Although an increasing number of RNA adenosine-to-inosine (A-to-I) editing sites are being discovered, how the editing frequencies of these sites are modulated to fine-tune protein function in adaptive responses is not well understood. A previous study screening for heat tolerance in Drosophila mutants discovered a hypnos-2 mutant strain that was later found to be defective in dADAR, the Drosophila gene encoding the A-to-I editing enzyme. This supports the hypothesis that cells and organisms respond to stressful environments by ADAR (adenosine deaminase acting on RNA)-mediated RNA editing. Here, we investigated changes in the RNA A-to-I editing frequencies of 30 Drosophila nervous system targets in response to heat shock, a stress acclimatization that requires the dADAR function. To our surprise, most of these nervous system editing targets showed reduced editing. Our results suggest that a change in RNA editing pattern is a mechanism by which organisms acclimate to drastic environmental change. However, how RNA editing confers heat resistance is more complicated and requires further investigation."xsd:string |
| http://purl.uniprot.org/citations/24018150 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.kjms.2013.01.001"xsd:string |
| http://purl.uniprot.org/citations/24018150 | http://purl.uniprot.org/core/author | "Chiu C.C."xsd:string |
| http://purl.uniprot.org/citations/24018150 | http://purl.uniprot.org/core/author | "Chang H.W."xsd:string |
| http://purl.uniprot.org/citations/24018150 | http://purl.uniprot.org/core/author | "Cho C.L."xsd:string |
| http://purl.uniprot.org/citations/24018150 | http://purl.uniprot.org/core/author | "Huang H.W."xsd:string |
| http://purl.uniprot.org/citations/24018150 | http://purl.uniprot.org/core/author | "Tseng C.N."xsd:string |
| http://purl.uniprot.org/citations/24018150 | http://purl.uniprot.org/core/author | "Wang H.M."xsd:string |
| http://purl.uniprot.org/citations/24018150 | http://purl.uniprot.org/core/author | "Stocker J."xsd:string |
| http://purl.uniprot.org/citations/24018150 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24018150 | http://purl.uniprot.org/core/name | "Kaohsiung J Med Sci"xsd:string |
| http://purl.uniprot.org/citations/24018150 | http://purl.uniprot.org/core/pages | "478-483"xsd:string |
| http://purl.uniprot.org/citations/24018150 | http://purl.uniprot.org/core/title | "Reduction of RNA A-to-I editing in Drosophila acclimated to heat shock."xsd:string |
| http://purl.uniprot.org/citations/24018150 | http://purl.uniprot.org/core/volume | "29"xsd:string |
| http://purl.uniprot.org/citations/24018150 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24018150 |
| http://purl.uniprot.org/citations/24018150 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24018150 |
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