| http://purl.uniprot.org/citations/24018823 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24018823 | http://www.w3.org/2000/01/rdf-schema#comment | "High cofilin-1 levels have been shown to be an accurate prognostic biomarker in non-small cell lung cancer (NSCLC) and a predictive factor in drug resistance. Herein we explore the role of cofilin-1 in cis-diamminedichloroplatinum(II) (cisplatin) resistance. We evaluated cofilin-1 levels in intrinsically cisplatin-resistant A549 (ICR-A549) cells and determined the cisplatin toxicity in A549 cells transiently transfected and overexpressing CFL1 plasmid. Moreover, expression levels (activity) of the CFL1 gene network were analyzed in a cisplatin-resistant human lung adenocarcinoma cell panel. ICR-A549 cells, selected by challenging parental cells with 10-fold drug GI50 value, presented a sixfold increase in cisplatin GI50 value and an increased cofilin-1 immunocontent (P < 0.01). In addition, cells transfected with cofilin-1 became more resistant to cisplatin (P < 0.01). High activity of the CFL1 gene network was found in a cisplatin-resistant adenocarcinoma cell panel (P < 0.01). In vitro evidences suggest that cofilin-1 is a biological predictor of cisplatin resistance, supporting new treatment initiatives based on cofilin-1 levels to guide chemotherapeutic interventions in NSCLC patients."xsd:string |
| http://purl.uniprot.org/citations/24018823 | http://purl.org/dc/terms/identifier | "doi:10.1007/s13277-013-1164-6"xsd:string |
| http://purl.uniprot.org/citations/24018823 | http://purl.uniprot.org/core/author | "Becker M."xsd:string |
| http://purl.uniprot.org/citations/24018823 | http://purl.uniprot.org/core/author | "Castro M.A."xsd:string |
| http://purl.uniprot.org/citations/24018823 | http://purl.uniprot.org/core/author | "Klamt F."xsd:string |
| http://purl.uniprot.org/citations/24018823 | http://purl.uniprot.org/core/author | "Muller C.B."xsd:string |
| http://purl.uniprot.org/citations/24018823 | http://purl.uniprot.org/core/author | "De Bastiani M.A."xsd:string |
| http://purl.uniprot.org/citations/24018823 | http://purl.uniprot.org/core/author | "Markoski M.M."xsd:string |
| http://purl.uniprot.org/citations/24018823 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24018823 | http://purl.uniprot.org/core/name | "Tumour Biol"xsd:string |
| http://purl.uniprot.org/citations/24018823 | http://purl.uniprot.org/core/pages | "1233-1238"xsd:string |
| http://purl.uniprot.org/citations/24018823 | http://purl.uniprot.org/core/title | "High cofilin-1 levels correlate with cisplatin resistance in lung adenocarcinomas."xsd:string |
| http://purl.uniprot.org/citations/24018823 | http://purl.uniprot.org/core/volume | "35"xsd:string |
| http://purl.uniprot.org/citations/24018823 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24018823 |
| http://purl.uniprot.org/citations/24018823 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24018823 |
| http://purl.uniprot.org/uniprot/#_B4E112-mappedCitation-24018823 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24018823 |
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| http://purl.uniprot.org/uniprot/#_P23528-mappedCitation-24018823 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24018823 |
| http://purl.uniprot.org/uniprot/#_V9HWI5-mappedCitation-24018823 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24018823 |
| http://purl.uniprot.org/uniprot/P23528 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24018823 |
| http://purl.uniprot.org/uniprot/V9HWI5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24018823 |
| http://purl.uniprot.org/uniprot/B4E112 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24018823 |
| http://purl.uniprot.org/uniprot/G3V1A4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24018823 |