| http://purl.uniprot.org/citations/24027274 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24027274 | http://www.w3.org/2000/01/rdf-schema#comment | "Spatial and temporal cues govern the genesis of a diverse array of neurons located in the dorsal spinal cord, including dI1-dI6, dIL(A), and dIL(B) subtypes, but their physiological functions are poorly understood. Here we generated a new line of conditional knock-out (CKO) mice, in which the homeobox gene Tlx3 was removed in dI5 and dIL(B) cells. In these CKO mice, development of a subset of excitatory neurons located in laminae I and II was impaired, including itch-related GRPR-expressing neurons, PKCγ-expressing neurons, and neurons expressing three neuropeptide genes: somatostatin, preprotachykinin 1, and the gastrin-releasing peptide. These CKO mice displayed marked deficits in generating nocifensive motor behaviors evoked by a range of pain-related or itch-related stimuli. The mutants also failed to exhibit escape response evoked by dynamic mechanical stimuli but retained the ability to sense innocuous cooling and/or warm. Thus, our studies provide new insight into the ontogeny of spinal neurons processing distinct sensory modalities."xsd:string |
| http://purl.uniprot.org/citations/24027274 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.5512-12.2013"xsd:string |
| http://purl.uniprot.org/citations/24027274 | http://purl.uniprot.org/core/author | "Cheng L."xsd:string |
| http://purl.uniprot.org/citations/24027274 | http://purl.uniprot.org/core/author | "Guo Z."xsd:string |
| http://purl.uniprot.org/citations/24027274 | http://purl.uniprot.org/core/author | "Xu Y."xsd:string |
| http://purl.uniprot.org/citations/24027274 | http://purl.uniprot.org/core/author | "Ma Q."xsd:string |
| http://purl.uniprot.org/citations/24027274 | http://purl.uniprot.org/core/author | "Birchmeier C."xsd:string |
| http://purl.uniprot.org/citations/24027274 | http://purl.uniprot.org/core/author | "Lopes C."xsd:string |
| http://purl.uniprot.org/citations/24027274 | http://purl.uniprot.org/core/author | "Wende H."xsd:string |
| http://purl.uniprot.org/citations/24027274 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24027274 | http://purl.uniprot.org/core/name | "J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/24027274 | http://purl.uniprot.org/core/pages | "14738-14748"xsd:string |
| http://purl.uniprot.org/citations/24027274 | http://purl.uniprot.org/core/title | "Ontogeny of excitatory spinal neurons processing distinct somatic sensory modalities."xsd:string |
| http://purl.uniprot.org/citations/24027274 | http://purl.uniprot.org/core/volume | "33"xsd:string |
| http://purl.uniprot.org/citations/24027274 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24027274 |
| http://purl.uniprot.org/citations/24027274 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24027274 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YWF9-mappedCitation-24027274 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24027274 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YWL7-mappedCitation-24027274 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24027274 |
| http://purl.uniprot.org/uniprot/#_A0A0A0MQA8-mappedCitation-24027274 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24027274 |
| http://purl.uniprot.org/uniprot/#_A0A0A0MQC7-mappedCitation-24027274 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24027274 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J0A6-mappedCitation-24027274 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24027274 |
| http://purl.uniprot.org/uniprot/#_A0A0U1RNZ0-mappedCitation-24027274 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24027274 |
| http://purl.uniprot.org/uniprot/#_A0A0U1RP04-mappedCitation-24027274 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24027274 |
| http://purl.uniprot.org/uniprot/#_A0A0U1RPF1-mappedCitation-24027274 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24027274 |