| http://purl.uniprot.org/citations/24030151 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24030151 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24030151 | http://www.w3.org/2000/01/rdf-schema#comment | "The evolutionarily conserved process of programmed cell death, apoptosis, is essential for development of multicellular organisms and is also a protective mechanism against cellular damage. We have identified dynein light chain 1 (DLC-1) as a new regulator of germ cell apoptosis in Caenorhabditis elegans. The DLC-1 protein is highly conserved across species and is a part of the dynein motor complex. There is, however, increasing evidence for dynein-independent functions of DLC-1, and our data describe a novel dynein-independent role. In mammalian cells, DLC-1 is important for cellular transport, cell division and regulation of protein activity, and it has been implicated in cancer. In C. elegans, we find that knockdown of dlc-1 by RNA interference (RNAi) induces excessive apoptosis in the germline but not in somatic cells during development. We show that DLC-1 mediates apoptosis through the genes lin-35, egl-1 and ced-13, which are all involved in the response to ionising radiation (IR)-induced apoptosis. In accordance with this, we show that IR cannot further induce apoptosis in dlc-1(RNAi) animals. Furthermore, we find that DLC-1 is functioning cell nonautonomously through the same pathway as kri-1 in response to IR-induced apoptosis and that DLC-1 regulates the levels of KRI-1. Our results strengthen the notion of a highly dynamic communication between somatic cells and germ cells in regulating the apoptotic process."xsd:string |
| http://purl.uniprot.org/citations/24030151 | http://purl.org/dc/terms/identifier | "doi:10.1038/cddis.2013.319"xsd:string |
| http://purl.uniprot.org/citations/24030151 | http://purl.org/dc/terms/identifier | "doi:10.1038/cddis.2013.319"xsd:string |
| http://purl.uniprot.org/citations/24030151 | http://purl.uniprot.org/core/author | "Olsen A."xsd:string |
| http://purl.uniprot.org/citations/24030151 | http://purl.uniprot.org/core/author | "Olsen A."xsd:string |
| http://purl.uniprot.org/citations/24030151 | http://purl.uniprot.org/core/author | "Morthorst T.H."xsd:string |
| http://purl.uniprot.org/citations/24030151 | http://purl.uniprot.org/core/author | "Morthorst T.H."xsd:string |
| http://purl.uniprot.org/citations/24030151 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24030151 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24030151 | http://purl.uniprot.org/core/name | "Cell Death Dis."xsd:string |
| http://purl.uniprot.org/citations/24030151 | http://purl.uniprot.org/core/name | "Cell Death Dis."xsd:string |
| http://purl.uniprot.org/citations/24030151 | http://purl.uniprot.org/core/pages | "E799"xsd:string |
| http://purl.uniprot.org/citations/24030151 | http://purl.uniprot.org/core/pages | "E799"xsd:string |
| http://purl.uniprot.org/citations/24030151 | http://purl.uniprot.org/core/title | "Cell-nonautonomous inhibition of radiation-induced apoptosis by dynein light chain 1 in Caenorhabditis elegans."xsd:string |
| http://purl.uniprot.org/citations/24030151 | http://purl.uniprot.org/core/title | "Cell-nonautonomous inhibition of radiation-induced apoptosis by dynein light chain 1 in Caenorhabditis elegans."xsd:string |
| http://purl.uniprot.org/citations/24030151 | http://purl.uniprot.org/core/volume | "4"xsd:string |
| http://purl.uniprot.org/citations/24030151 | http://purl.uniprot.org/core/volume | "4"xsd:string |
| http://purl.uniprot.org/citations/24030151 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24030151 |
| http://purl.uniprot.org/citations/24030151 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24030151 |
| http://purl.uniprot.org/citations/24030151 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24030151 |
| http://purl.uniprot.org/citations/24030151 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24030151 |
| http://purl.uniprot.org/uniprot/Q22799 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/24030151 |
| http://purl.uniprot.org/uniprot/Q22799#attribution-E45FE324128FDBF133E8926AB9624801 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/24030151 |