| http://purl.uniprot.org/citations/24030809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24030809 | http://www.w3.org/2000/01/rdf-schema#comment | "Human type I interferons (IFNs) include IFN-β and 12 subtypes of IFN-α. During viral infection, infiltrating memory CD4(+) T cells are exposed to IFNs, but their impact on memory T-cell function is poorly understood. To address this, we pretreated PBMCs with different IFNs for 16 h before stimulation with Staphylococcus aureus enterotoxin B and measured cytokine expression by flow cytometry. IFN-α8 and -α10 most potently enhanced expression of IFN-γ, IL-2, and IL-4. Potency among the subtypes differed most at doses between 10 and 100 U/mL. While enhancement of IL-2 and IL-4 correlated with the time of preincubation with type I IFN, IFN-γ production was enhanced best when IFN-α was added immediately preceding or simultaneously with T-cell stimulation. Comparison of T-cell responses to multiple doses of Staphylococcus aureus enterotoxin B and to peptide libraries from RSV or CMV demonstrated that IFN-α best enhanced cytokine expression when CD4(+) T cells were suboptimally stimulated. We conclude that type I IFNs enhance Th1 and Th2 function with dose dependency and subtype specificity, and best when T-cell stimulation is suboptimal. While type I IFNs may beneficially enhance CD4(+) T-cell memory responses to vaccines or viral pathogens, they may also enhance the function of resident Th2 cells and exacerbate allergic inflammation."xsd:string |
| http://purl.uniprot.org/citations/24030809 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.201243288"xsd:string |
| http://purl.uniprot.org/citations/24030809 | http://purl.uniprot.org/core/author | "Graham B.S."xsd:string |
| http://purl.uniprot.org/citations/24030809 | http://purl.uniprot.org/core/author | "Liu J."xsd:string |
| http://purl.uniprot.org/citations/24030809 | http://purl.uniprot.org/core/author | "Johnson T.R."xsd:string |
| http://purl.uniprot.org/citations/24030809 | http://purl.uniprot.org/core/author | "Hillyer P."xsd:string |
| http://purl.uniprot.org/citations/24030809 | http://purl.uniprot.org/core/author | "Rabin R.L."xsd:string |
| http://purl.uniprot.org/citations/24030809 | http://purl.uniprot.org/core/author | "Gold D.M."xsd:string |
| http://purl.uniprot.org/citations/24030809 | http://purl.uniprot.org/core/author | "Dougherty D."xsd:string |
| http://purl.uniprot.org/citations/24030809 | http://purl.uniprot.org/core/author | "Raviv N."xsd:string |
| http://purl.uniprot.org/citations/24030809 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24030809 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/24030809 | http://purl.uniprot.org/core/pages | "3197-3208"xsd:string |
| http://purl.uniprot.org/citations/24030809 | http://purl.uniprot.org/core/title | "Subtypes of type I IFN differentially enhance cytokine expression by suboptimally stimulated CD4(+) T cells."xsd:string |
| http://purl.uniprot.org/citations/24030809 | http://purl.uniprot.org/core/volume | "43"xsd:string |
| http://purl.uniprot.org/citations/24030809 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24030809 |
| http://purl.uniprot.org/citations/24030809 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24030809 |
| http://purl.uniprot.org/uniprot/#_A0A7R8C2Z1-mappedCitation-24030809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24030809 |
| http://purl.uniprot.org/uniprot/#_A0A7R8C381-mappedCitation-24030809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24030809 |
| http://purl.uniprot.org/uniprot/#_P01566-mappedCitation-24030809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24030809 |
| http://purl.uniprot.org/uniprot/#_P32881-mappedCitation-24030809 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24030809 |
| http://purl.uniprot.org/uniprot/A0A7R8C2Z1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24030809 |
| http://purl.uniprot.org/uniprot/P01566 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24030809 |
| http://purl.uniprot.org/uniprot/A0A7R8C381 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24030809 |