| http://purl.uniprot.org/citations/24034246 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24034246 | http://www.w3.org/2000/01/rdf-schema#comment | "The ATP-dependent chromatin-remodeling complex SWR1 exchanges a variant histone H2A.Z/H2B dimer for a canonical H2A/H2B dimer at nucleosomes flanking histone-depleted regions, such as promoters. This localization of H2A.Z is conserved throughout eukaryotes. SWR1 is a 1 megadalton complex containing 14 different polypeptides, including the AAA+ ATPases Rvb1 and Rvb2. Using electron microscopy, we obtained the three-dimensional structure of SWR1 and mapped its major functional components. Our data show that SWR1 contains a single heterohexameric Rvb1/Rvb2 ring that, together with the catalytic subunit Swr1, brackets two independently assembled multisubunit modules. We also show that SWR1 undergoes a large conformational change upon engaging a limited region of the nucleosome core particle. Our work suggests an important structural role for the Rvbs and a distinct substrate-handling mode by SWR1, thereby providing a structural framework for understanding the complex dimer-exchange reaction."xsd:string |
| http://purl.uniprot.org/citations/24034246 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2013.08.018"xsd:string |
| http://purl.uniprot.org/citations/24034246 | http://purl.uniprot.org/core/author | "Aebersold R."xsd:string |
| http://purl.uniprot.org/citations/24034246 | http://purl.uniprot.org/core/author | "Wu C."xsd:string |
| http://purl.uniprot.org/citations/24034246 | http://purl.uniprot.org/core/author | "Wei D."xsd:string |
| http://purl.uniprot.org/citations/24034246 | http://purl.uniprot.org/core/author | "Ranjan A."xsd:string |
| http://purl.uniprot.org/citations/24034246 | http://purl.uniprot.org/core/author | "Leschziner A.E."xsd:string |
| http://purl.uniprot.org/citations/24034246 | http://purl.uniprot.org/core/author | "Stengel F."xsd:string |
| http://purl.uniprot.org/citations/24034246 | http://purl.uniprot.org/core/author | "Nguyen V.Q."xsd:string |
| http://purl.uniprot.org/citations/24034246 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24034246 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/24034246 | http://purl.uniprot.org/core/pages | "1220-1231"xsd:string |
| http://purl.uniprot.org/citations/24034246 | http://purl.uniprot.org/core/title | "Molecular architecture of the ATP-dependent chromatin-remodeling complex SWR1."xsd:string |
| http://purl.uniprot.org/citations/24034246 | http://purl.uniprot.org/core/volume | "154"xsd:string |
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