| http://purl.uniprot.org/citations/24034253 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24034253 | http://www.w3.org/2000/01/rdf-schema#comment | "G-protein-coupled receptors (GPCRs) are known to possess two different conformations, active and inactive, and they spontaneously alternate between the two in the absence of ligands. Here, we analyzed the agonist-independent GPCR activity for its possible role in receptor-instructed axonal projection. We generated transgenic mice expressing activity mutants of the β2-adrenergic receptor, a well-characterized GPCR with the highest homology to odorant receptors (ORs). We found that mutants with altered agonist-independent activity changed the transcription levels of axon-targeting molecules--e.g., Neuropilin-1 and Plexin-A1--but not of glomerular segregation molecules--e.g., Kirrel2 and Kirrel3--thus causing shifts in glomerular locations along the anterior-posterior (A-P) axis. Knockout and in vitro experiments demonstrated that Gs, but not Golf, is responsible for mediating the agonist-independent GPCR activity. We conclude that the equilibrium of conformational transitions set by each OR is the major determinant of expression levels of A-P-targeting molecules."xsd:string |
| http://purl.uniprot.org/citations/24034253 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2013.08.033"xsd:string |
| http://purl.uniprot.org/citations/24034253 | http://purl.uniprot.org/core/author | "Abe T."xsd:string |
| http://purl.uniprot.org/citations/24034253 | http://purl.uniprot.org/core/author | "Chen M."xsd:string |
| http://purl.uniprot.org/citations/24034253 | http://purl.uniprot.org/core/author | "Imai T."xsd:string |
| http://purl.uniprot.org/citations/24034253 | http://purl.uniprot.org/core/author | "Sakano H."xsd:string |
| http://purl.uniprot.org/citations/24034253 | http://purl.uniprot.org/core/author | "Saito H."xsd:string |
| http://purl.uniprot.org/citations/24034253 | http://purl.uniprot.org/core/author | "Storm D.R."xsd:string |
| http://purl.uniprot.org/citations/24034253 | http://purl.uniprot.org/core/author | "Takeuchi H."xsd:string |
| http://purl.uniprot.org/citations/24034253 | http://purl.uniprot.org/core/author | "Nakashima A."xsd:string |
| http://purl.uniprot.org/citations/24034253 | http://purl.uniprot.org/core/author | "Nishizumi H."xsd:string |
| http://purl.uniprot.org/citations/24034253 | http://purl.uniprot.org/core/author | "Kiyonari H."xsd:string |
| http://purl.uniprot.org/citations/24034253 | http://purl.uniprot.org/core/author | "Weinstein L.S."xsd:string |
| http://purl.uniprot.org/citations/24034253 | http://purl.uniprot.org/core/author | "Yu C.R."xsd:string |
| http://purl.uniprot.org/citations/24034253 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24034253 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/24034253 | http://purl.uniprot.org/core/pages | "1314-1325"xsd:string |
| http://purl.uniprot.org/citations/24034253 | http://purl.uniprot.org/core/title | "Agonist-independent GPCR activity regulates anterior-posterior targeting of olfactory sensory neurons."xsd:string |
| http://purl.uniprot.org/citations/24034253 | http://purl.uniprot.org/core/volume | "154"xsd:string |
| http://purl.uniprot.org/citations/24034253 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24034253 |
| http://purl.uniprot.org/citations/24034253 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24034253 |
| http://purl.uniprot.org/uniprot/#_P63094-mappedCitation-24034253 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24034253 |
| http://purl.uniprot.org/uniprot/#_A0A571BDL4-mappedCitation-24034253 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24034253 |
| http://purl.uniprot.org/uniprot/#_A0A571BE25-mappedCitation-24034253 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24034253 |