| http://purl.uniprot.org/citations/24034695 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24034695 | http://www.w3.org/2000/01/rdf-schema#comment | "The neurotrophin receptor TrkC was recently identified as a dependence receptor, and, as such, it triggers apoptosis in the absence of its ligand, NT-3. The molecular mechanism for apoptotic engagement involves the double cleavage of the receptor's intracellular domain, leading to the formation of a proapoptotic "killer" fragment (TrkC KF). Here, we show that TrkC KF interacts with Cobra1, a putative cofactor of BRCA1, and that Cobra1 is required for TrkC-induced apoptosis. We also show that, in the developing chick neural tube, NT-3 silencing is associated with neuroepithelial cell death that is rescued by Cobra1 silencing. Cobra1 shuttles TrkC KF to the mitochondria, where it promotes Bax activation, cytochrome c release, and apoptosome-dependent apoptosis. Thus, we propose that, in the absence of NT-3, the proteolytic cleavage of TrkC leads to the release of a killer fragment that triggers mitochondria-dependent apoptosis via the recruitment of Cobra1."xsd:string |
| http://purl.uniprot.org/citations/24034695 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2013.08.021"xsd:string |
| http://purl.uniprot.org/citations/24034695 | http://purl.uniprot.org/core/author | "Menard M."xsd:string |
| http://purl.uniprot.org/citations/24034695 | http://purl.uniprot.org/core/author | "Lefebvre J."xsd:string |
| http://purl.uniprot.org/citations/24034695 | http://purl.uniprot.org/core/author | "Tulasne D."xsd:string |
| http://purl.uniprot.org/citations/24034695 | http://purl.uniprot.org/core/author | "Arumae U."xsd:string |
| http://purl.uniprot.org/citations/24034695 | http://purl.uniprot.org/core/author | "Llambi F."xsd:string |
| http://purl.uniprot.org/citations/24034695 | http://purl.uniprot.org/core/author | "Mehlen P."xsd:string |
| http://purl.uniprot.org/citations/24034695 | http://purl.uniprot.org/core/author | "Tauszig-Delamasure S."xsd:string |
| http://purl.uniprot.org/citations/24034695 | http://purl.uniprot.org/core/author | "Yu L.Y."xsd:string |
| http://purl.uniprot.org/citations/24034695 | http://purl.uniprot.org/core/author | "Le Douarin N."xsd:string |
| http://purl.uniprot.org/citations/24034695 | http://purl.uniprot.org/core/author | "Ichim G."xsd:string |
| http://purl.uniprot.org/citations/24034695 | http://purl.uniprot.org/core/author | "Dupin E."xsd:string |
| http://purl.uniprot.org/citations/24034695 | http://purl.uniprot.org/core/author | "Jarrosson-Wuilleme L."xsd:string |
| http://purl.uniprot.org/citations/24034695 | http://purl.uniprot.org/core/author | "Genevois A.L."xsd:string |
| http://purl.uniprot.org/citations/24034695 | http://purl.uniprot.org/core/author | "Coelho-Aguiar J.M."xsd:string |
| http://purl.uniprot.org/citations/24034695 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24034695 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/24034695 | http://purl.uniprot.org/core/pages | "632-646"xsd:string |
| http://purl.uniprot.org/citations/24034695 | http://purl.uniprot.org/core/title | "The dependence receptor TrkC triggers mitochondria-dependent apoptosis upon Cobra-1 recruitment."xsd:string |
| http://purl.uniprot.org/citations/24034695 | http://purl.uniprot.org/core/volume | "51"xsd:string |
| http://purl.uniprot.org/citations/24034695 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24034695 |
| http://purl.uniprot.org/citations/24034695 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24034695 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YWF9-mappedCitation-24034695 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24034695 |