| http://purl.uniprot.org/citations/24035500 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24035500 | http://www.w3.org/2000/01/rdf-schema#comment | "A chemicogenetic screen was performed in budding yeast mutants that have a weakened replication stress response. This identified an inhibitor of target of rapamycin (TOR) complexes 1 and 2 that selectively enhances the sensitivity of sgs1Δ cells to hydroxyurea and camptothecin. More importantly, the inhibitor has strong synthetic lethality in combination with either the break-inducing antibiotic Zeocin or ionizing radiation, independent of the strain background. Lethality correlates with a rapid fragmentation of chromosomes that occurs only when TORC2, but not TORC1, is repressed. Genetic inhibition of Tor2 kinase, or its downstream effector kinases Ypk1/Ypk2, conferred similar synergistic effects in the presence of Zeocin. Given that Ypk1/Ypk2 controls the actin cytoskeleton, we tested the effects of actin modulators latrunculin A and jasplakinolide. These phenocopy TORC2 inhibition on Zeocin, although modulation of calcineurin-sensitive transcription does not. These results implicate TORC2-mediated actin filament regulation in the survival of low levels of DNA damage."xsd:string |
| http://purl.uniprot.org/citations/24035500 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2013.08.019"xsd:string |
| http://purl.uniprot.org/citations/24035500 | http://purl.uniprot.org/core/author | "Shimada K."xsd:string |
| http://purl.uniprot.org/citations/24035500 | http://purl.uniprot.org/core/author | "Stahl M."xsd:string |
| http://purl.uniprot.org/citations/24035500 | http://purl.uniprot.org/core/author | "Filipuzzi I."xsd:string |
| http://purl.uniprot.org/citations/24035500 | http://purl.uniprot.org/core/author | "Hoepfner D."xsd:string |
| http://purl.uniprot.org/citations/24035500 | http://purl.uniprot.org/core/author | "Studer C."xsd:string |
| http://purl.uniprot.org/citations/24035500 | http://purl.uniprot.org/core/author | "Movva N.R."xsd:string |
| http://purl.uniprot.org/citations/24035500 | http://purl.uniprot.org/core/author | "Loewith R."xsd:string |
| http://purl.uniprot.org/citations/24035500 | http://purl.uniprot.org/core/author | "Helliwell S.B."xsd:string |
| http://purl.uniprot.org/citations/24035500 | http://purl.uniprot.org/core/author | "Gasser S.M."xsd:string |
| http://purl.uniprot.org/citations/24035500 | http://purl.uniprot.org/core/author | "Seeber A."xsd:string |
| http://purl.uniprot.org/citations/24035500 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24035500 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/24035500 | http://purl.uniprot.org/core/pages | "829-839"xsd:string |
| http://purl.uniprot.org/citations/24035500 | http://purl.uniprot.org/core/title | "TORC2 signaling pathway guarantees genome stability in the face of DNA strand breaks."xsd:string |
| http://purl.uniprot.org/citations/24035500 | http://purl.uniprot.org/core/volume | "51"xsd:string |
| http://purl.uniprot.org/citations/24035500 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24035500 |
| http://purl.uniprot.org/citations/24035500 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24035500 |
| http://purl.uniprot.org/uniprot/#_A0A8H4BXT0-mappedCitation-24035500 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24035500 |
| http://purl.uniprot.org/uniprot/#_P39102-mappedCitation-24035500 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24035500 |
| http://purl.uniprot.org/uniprot/#_P40061-mappedCitation-24035500 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24035500 |
| http://purl.uniprot.org/uniprot/#_P40215-mappedCitation-24035500 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24035500 |
| http://purl.uniprot.org/uniprot/#_P41318-mappedCitation-24035500 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24035500 |