| http://purl.uniprot.org/citations/24036217 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24036217 | http://www.w3.org/2000/01/rdf-schema#comment | "Tumour cells alter their gene expression profile to acquire a more invasive and resistant phenotype. Overexpression of the signalling adaptor protein ShcD in melanoma was found to be a prerequisite for melanoma migration and invasion. In common with other Shc proteins, ShcD has been shown to be involved in coupling receptor tyrosine kinases to the Ras-mitogen activated protein kinase signalling pathway, and to have a predominant cytoplasmic distribution. Here we report that ShcD can exist within the nucleus, and show that its CH2 domain has a critical role in nuclear export of ShcD. Analysis of GFP-tagged ShcD mutants containing deletions or amino acid substitutions within the CH2 domain revealed (83)LCTLIPRM(90) as a functional nuclear export signal. We have further demonstrated that ShcD accumulates in the nucleus upon hydrogen peroxide treatment in FLAG-ShcD expressing HEK293 cells, as well as 518.A2 melanoma cells. Cross linking experiments showed that a proportion of ShcD is associated with DNA. Moreover we have shown that ShcD fused to the GAL4 DNA binding domain can drive transcription of a GAL4 site-driven luciferase reporter, suggesting a role for ShcD in regulating gene transcription. We suggest that ShcD nuclear translocation might provide melanoma cells with a mechanism that enables them to resist DNA damage due to oxidative stress."xsd:string |
| http://purl.uniprot.org/citations/24036217 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cellsig.2013.09.003"xsd:string |
| http://purl.uniprot.org/citations/24036217 | http://purl.uniprot.org/core/author | "Prigent S.A."xsd:string |
| http://purl.uniprot.org/citations/24036217 | http://purl.uniprot.org/core/author | "Ahmed S.B."xsd:string |
| http://purl.uniprot.org/citations/24036217 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24036217 | http://purl.uniprot.org/core/name | "Cell Signal"xsd:string |
| http://purl.uniprot.org/citations/24036217 | http://purl.uniprot.org/core/pages | "32-40"xsd:string |
| http://purl.uniprot.org/citations/24036217 | http://purl.uniprot.org/core/title | "A nuclear export signal and oxidative stress regulate ShcD subcellular localisation: a potential role for ShcD in the nucleus."xsd:string |
| http://purl.uniprot.org/citations/24036217 | http://purl.uniprot.org/core/volume | "26"xsd:string |
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