| http://purl.uniprot.org/citations/24037986 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24037986 | http://www.w3.org/2000/01/rdf-schema#comment | "Regulation of the hematopoietic transcription factor PU.1, a member of the ETS family, plays a critical role in the development of blood cells and in leukemia. The dosage of PU.1 has been shown to cause a shift in myelomonocytic progenitor fate. Pin1 is a unique substrate-specific enzyme that can isomerize phospho-Ser/Thr-Pro peptide bonds, accelerating the conformational change in its substrates between a cis and a trans form. Such activity has been demonstrated to be a tightly controlled mechanism regulating a wide variety of protein functions under both normal physiological and pathological conditions. We have previously reported that a conformational change in Runx2 induced by Pin1 is essential for its function in osteogenesis in vitro and in vivo. In this study, we show that the Pin1-mediated conformational change in Runx1 enhances its acetylation and stabilization and, consequently, enhances its transacting activity. The increased acetylation of Runx1 represses PU.1 transcription in pre-monocytes. Conversely, the lack of (or the inhibition of) Pin1 increases PU.1 transcription in vitro and in vivo in pre-monocytes and in the spleen tissue. Pin1 KO mice have an increased CD11b(+) /F4/80(+) cell population and F4/80 protein expression in spleen. From our data, we can conclude that the conformational change in Runx1 induced by Pin1 represses PU.1 transcription in pre-monocytes and influences the commitment to the monocyte lineage. The dosage of PU.1 is a crucial factor in acute myeloid leukemia (AML), and Pin1 may thus be a useful target for controlling PU.1-dependent hematopoiesis, as well as leukemogenesis."xsd:string |
| http://purl.uniprot.org/citations/24037986 | http://purl.org/dc/terms/identifier | "doi:10.1002/jcp.24462"xsd:string |
| http://purl.uniprot.org/citations/24037986 | http://purl.uniprot.org/core/author | "Woo K.M."xsd:string |
| http://purl.uniprot.org/citations/24037986 | http://purl.uniprot.org/core/author | "Islam R."xsd:string |
| http://purl.uniprot.org/citations/24037986 | http://purl.uniprot.org/core/author | "Baek J.H."xsd:string |
| http://purl.uniprot.org/citations/24037986 | http://purl.uniprot.org/core/author | "Ryoo H.M."xsd:string |
| http://purl.uniprot.org/citations/24037986 | http://purl.uniprot.org/core/author | "Yoon W.J."xsd:string |
| http://purl.uniprot.org/citations/24037986 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/24037986 | http://purl.uniprot.org/core/name | "J Cell Physiol"xsd:string |
| http://purl.uniprot.org/citations/24037986 | http://purl.uniprot.org/core/pages | "443-452"xsd:string |
| http://purl.uniprot.org/citations/24037986 | http://purl.uniprot.org/core/title | "Pin1-mediated prolyl isomerization of Runx1 affects PU.1 expression in pre-monocytes."xsd:string |
| http://purl.uniprot.org/citations/24037986 | http://purl.uniprot.org/core/volume | "229"xsd:string |
| http://purl.uniprot.org/citations/24037986 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24037986 |
| http://purl.uniprot.org/citations/24037986 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24037986 |
| http://purl.uniprot.org/uniprot/#_A0A087WPL0-mappedCitation-24037986 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24037986 |
| http://purl.uniprot.org/uniprot/#_E9QAI9-mappedCitation-24037986 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24037986 |
| http://purl.uniprot.org/uniprot/#_A0A087WR05-mappedCitation-24037986 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24037986 |
| http://purl.uniprot.org/uniprot/#_E9Q6W1-mappedCitation-24037986 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24037986 |
| http://purl.uniprot.org/uniprot/#_G3UWD2-mappedCitation-24037986 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24037986 |
| http://purl.uniprot.org/uniprot/#_G3X9W7-mappedCitation-24037986 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24037986 |
| http://purl.uniprot.org/uniprot/#_Q03347-mappedCitation-24037986 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24037986 |
| http://purl.uniprot.org/uniprot/#_Q3UM65-mappedCitation-24037986 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24037986 |
| http://purl.uniprot.org/uniprot/#_P17433-mappedCitation-24037986 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24037986 |
| http://purl.uniprot.org/uniprot/#_Q3UTI7-mappedCitation-24037986 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24037986 |