| http://purl.uniprot.org/citations/24038359 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24038359 | http://www.w3.org/2000/01/rdf-schema#comment | "E2F2 is essential for the maintenance of T lymphocyte quiescence. To identify the full set of E2F2 target genes, and to gain further understanding of the role of E2F2 in transcriptional regulation, we have performed ChIP-chip analyses across the genome of lymph node-derived T lymphocytes. Here we show that during quiescence, E2F2 binds the promoters of a large number of genes involved in DNA metabolism and cell cycle regulation, concomitant with their transcriptional silencing. A comparison of ChIP-chip data with expression profiling data on resting E2f2(-)(/)(-) T lymphocytes identified a subset of 51 E2F2-specific target genes, most of which are upregulated on E2F2 loss. Luciferase reporter assays showed a retinoblastoma-independent role for E2F2 in the negative regulation of these target genes. Importantly, we show that the DNA binding activity of the transcription factor CREB contributes to E2F2-mediated repression of Mcm5 and Chk1 promoters. siRNA-mediated CREB knockdown, expression of a dominant negative KCREB mutant or disruption of CREB binding by mutating a CRE motif on Mcm5 promoter, relieved E2F2-mediated transcriptional repression. Taken together, our data uncover a new regulatory mechanism for E2F-mediated transcriptional control, whereby E2F2 and CREB cooperate in the transcriptional repression of a subset of E2F2 target genes."xsd:string |
| http://purl.uniprot.org/citations/24038359 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/gkt821"xsd:string |
| http://purl.uniprot.org/citations/24038359 | http://purl.uniprot.org/core/author | "Rodriguez J.A."xsd:string |
| http://purl.uniprot.org/citations/24038359 | http://purl.uniprot.org/core/author | "Fullaondo A."xsd:string |
| http://purl.uniprot.org/citations/24038359 | http://purl.uniprot.org/core/author | "Osinalde N."xsd:string |
| http://purl.uniprot.org/citations/24038359 | http://purl.uniprot.org/core/author | "Apraiz A."xsd:string |
| http://purl.uniprot.org/citations/24038359 | http://purl.uniprot.org/core/author | "Zubiaga A.M."xsd:string |
| http://purl.uniprot.org/citations/24038359 | http://purl.uniprot.org/core/author | "Laresgoiti U."xsd:string |
| http://purl.uniprot.org/citations/24038359 | http://purl.uniprot.org/core/author | "Mitxelena J."xsd:string |
| http://purl.uniprot.org/citations/24038359 | http://purl.uniprot.org/core/author | "Olea M."xsd:string |
| http://purl.uniprot.org/citations/24038359 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24038359 | http://purl.uniprot.org/core/name | "Nucleic Acids Res"xsd:string |
| http://purl.uniprot.org/citations/24038359 | http://purl.uniprot.org/core/pages | "10185-10198"xsd:string |
| http://purl.uniprot.org/citations/24038359 | http://purl.uniprot.org/core/title | "E2F2 and CREB cooperatively regulate transcriptional activity of cell cycle genes."xsd:string |
| http://purl.uniprot.org/citations/24038359 | http://purl.uniprot.org/core/volume | "41"xsd:string |
| http://purl.uniprot.org/citations/24038359 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24038359 |
| http://purl.uniprot.org/citations/24038359 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24038359 |
| http://purl.uniprot.org/uniprot/#_P56931-mappedCitation-24038359 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24038359 |
| http://purl.uniprot.org/uniprot/#_Q3TZQ9-mappedCitation-24038359 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24038359 |
| http://purl.uniprot.org/uniprot/#_Q3U008-mappedCitation-24038359 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24038359 |
| http://purl.uniprot.org/uniprot/#_Q8BJ38-mappedCitation-24038359 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24038359 |
| http://purl.uniprot.org/uniprot/P56931 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24038359 |
| http://purl.uniprot.org/uniprot/Q8BJ38 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24038359 |
| http://purl.uniprot.org/uniprot/Q3TZQ9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24038359 |