| http://purl.uniprot.org/citations/24039741 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24039741 | http://www.w3.org/2000/01/rdf-schema#comment | "The yeast Saccharomyces cerevisiae normally selects bud sites (and hence axes of cell polarization) in one of two distinct patterns, the axial pattern of haploid cells and the bipolar pattern of diploid cells. These patterns depend on distinct sets of cortical-marker proteins that transmit positional information through a common signaling pathway based on a Ras-type GTPase. It has been reported previously that various proteins of the endocytic pathway may be involved in determining the bipolar pattern but not the axial pattern. To explore this question systematically, we constructed and analyzed congenic haploid and diploid deletion mutants for 14 genes encoding proteins that are involved in endocytosis. The mutants displayed a wide range of severities in their overall endocytosis defects, as judged by their growth rates and abilities to take up the lipophilic dye FM 4-64. Consistent with the previous reports, none of the mutants displayed a significant defect in axial budding, but they displayed defects in bipolar budding that were roughly correlated with the severities of their overall endocytosis defects. Both the details of the mutant budding patterns and direct examination of GFP-tagged marker proteins suggested that both initial formation and maintenance of the normally persistent bipolar marks depend on endocytosis, as well as polarized exocytosis, in actively growing cells. Interestingly, maintenance of the bipolar marks in non-growing cells did not appear to require normal levels of endocytosis. In some cases, there was a striking lack of correlation between the overall severities of the general-endocytosis defect and the bud-site selection defect, suggesting that various endocytosis proteins may differ in their importance for the uptake of various plasma-membrane targets."xsd:string |
| http://purl.uniprot.org/citations/24039741 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0072123"xsd:string |
| http://purl.uniprot.org/citations/24039741 | http://purl.uniprot.org/core/author | "Nakashima K."xsd:string |
| http://purl.uniprot.org/citations/24039741 | http://purl.uniprot.org/core/author | "Pringle J.R."xsd:string |
| http://purl.uniprot.org/citations/24039741 | http://purl.uniprot.org/core/author | "Tuo S."xsd:string |
| http://purl.uniprot.org/citations/24039741 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24039741 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/24039741 | http://purl.uniprot.org/core/pages | "e72123"xsd:string |
| http://purl.uniprot.org/citations/24039741 | http://purl.uniprot.org/core/title | "Role of endocytosis in localization and maintenance of the spatial markers for bud-site selection in yeast."xsd:string |
| http://purl.uniprot.org/citations/24039741 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/24039741 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24039741 |
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