| http://purl.uniprot.org/citations/24046321 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24046321 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24046321 | http://www.w3.org/2000/01/rdf-schema#comment | "Blood vessels and neurons grow often side by side. However, the molecular and cellular mechanisms underlying their parallel development remain unclear. Here, we report that a subpopulation of secondary motoneurons extends axons ventrally outside of the neural tubes and rostrocaudally as a fascicle beneath the dorsal aorta (DA) in zebrafish. We tried to clarify the mechanism by which these motoneuron axons grow beneath the DA and found that Vegfc in the DA and Vegfr3 in the motoneurons were essential for the axon growth. Forced expression of either Vegfc in arteries or Vegfr3 in motoneurons resulted in enhanced axon growth of motoneurons over the DA. Both vegfr3 morphants and vegfc morphants lost the alignment of motoneuron axons with DA. In addition, forced expression of two mutant forms of Vegfr3 in motoneurons, potentially trapping endogenous Vegfc, resulted in failure of growth of motoneuron axons beneath the DA. Finally, a vegfr3 mutant fish lacked the motoneuron axons beneath the DA. Collectively, Vegfc from the preformed DA guides the axon growth of secondary motoneurons."xsd:string |
| http://purl.uniprot.org/citations/24046321 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.091702"xsd:string |
| http://purl.uniprot.org/citations/24046321 | http://purl.uniprot.org/core/author | "Ando K."xsd:string |
| http://purl.uniprot.org/citations/24046321 | http://purl.uniprot.org/core/author | "Ando K."xsd:string |
| http://purl.uniprot.org/citations/24046321 | http://purl.uniprot.org/core/author | "Mochizuki N."xsd:string |
| http://purl.uniprot.org/citations/24046321 | http://purl.uniprot.org/core/author | "Mochizuki N."xsd:string |
| http://purl.uniprot.org/citations/24046321 | http://purl.uniprot.org/core/author | "Fukuhara S."xsd:string |
| http://purl.uniprot.org/citations/24046321 | http://purl.uniprot.org/core/author | "Fukuhara S."xsd:string |
| http://purl.uniprot.org/citations/24046321 | http://purl.uniprot.org/core/author | "Hibi M."xsd:string |
| http://purl.uniprot.org/citations/24046321 | http://purl.uniprot.org/core/author | "Hibi M."xsd:string |
| http://purl.uniprot.org/citations/24046321 | http://purl.uniprot.org/core/author | "Alitalo K."xsd:string |
| http://purl.uniprot.org/citations/24046321 | http://purl.uniprot.org/core/author | "Alitalo K."xsd:string |
| http://purl.uniprot.org/citations/24046321 | http://purl.uniprot.org/core/author | "Kwon H.B."xsd:string |
| http://purl.uniprot.org/citations/24046321 | http://purl.uniprot.org/core/author | "Kwon H.B."xsd:string |
| http://purl.uniprot.org/citations/24046321 | http://purl.uniprot.org/core/author | "Kawakami K."xsd:string |
| http://purl.uniprot.org/citations/24046321 | http://purl.uniprot.org/core/author | "Kawakami K."xsd:string |
| http://purl.uniprot.org/citations/24046321 | http://purl.uniprot.org/core/author | "Asakawa K."xsd:string |
| http://purl.uniprot.org/citations/24046321 | http://purl.uniprot.org/core/author | "Asakawa K."xsd:string |
| http://purl.uniprot.org/citations/24046321 | http://purl.uniprot.org/core/author | "Kim K.W."xsd:string |
| http://purl.uniprot.org/citations/24046321 | http://purl.uniprot.org/core/author | "Kim K.W."xsd:string |
| http://purl.uniprot.org/citations/24046321 | http://purl.uniprot.org/core/author | "Kwon Y.G."xsd:string |
| http://purl.uniprot.org/citations/24046321 | http://purl.uniprot.org/core/author | "Kwon Y.G."xsd:string |
| http://purl.uniprot.org/citations/24046321 | http://purl.uniprot.org/core/author | "Kashiwada T."xsd:string |