| http://purl.uniprot.org/citations/24051248 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24051248 | http://www.w3.org/2000/01/rdf-schema#comment | "Circadian clocks are self-sustained cellular oscillators that synchronize oxidative and reductive cycles in anticipation of the solar cycle. We found that the clock transcription feedback loop produces cycles of nicotinamide adenine dinucleotide (NAD(+)) biosynthesis, adenosine triphosphate production, and mitochondrial respiration through modulation of mitochondrial protein acetylation to synchronize oxidative metabolic pathways with the 24-hour fasting and feeding cycle. Circadian control of the activity of the NAD(+)-dependent deacetylase sirtuin 3 (SIRT3) generated rhythms in the acetylation and activity of oxidative enzymes and respiration in isolated mitochondria, and NAD(+) supplementation restored protein deacetylation and enhanced oxygen consumption in circadian mutant mice. Thus, circadian control of NAD(+) bioavailability modulates mitochondrial oxidative function and organismal metabolism across the daily cycles of fasting and feeding."xsd:string |
| http://purl.uniprot.org/citations/24051248 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1243417"xsd:string |
| http://purl.uniprot.org/citations/24051248 | http://purl.uniprot.org/core/author | "Kobayashi Y."xsd:string |
| http://purl.uniprot.org/citations/24051248 | http://purl.uniprot.org/core/author | "Yu W."xsd:string |
| http://purl.uniprot.org/citations/24051248 | http://purl.uniprot.org/core/author | "Ilkayeva O."xsd:string |
| http://purl.uniprot.org/citations/24051248 | http://purl.uniprot.org/core/author | "Newgard C.B."xsd:string |
| http://purl.uniprot.org/citations/24051248 | http://purl.uniprot.org/core/author | "Denu J.M."xsd:string |
| http://purl.uniprot.org/citations/24051248 | http://purl.uniprot.org/core/author | "Mrksich M."xsd:string |
| http://purl.uniprot.org/citations/24051248 | http://purl.uniprot.org/core/author | "Gius D."xsd:string |
| http://purl.uniprot.org/citations/24051248 | http://purl.uniprot.org/core/author | "Bass J."xsd:string |
| http://purl.uniprot.org/citations/24051248 | http://purl.uniprot.org/core/author | "Marcheva B."xsd:string |
| http://purl.uniprot.org/citations/24051248 | http://purl.uniprot.org/core/author | "Omura C."xsd:string |
| http://purl.uniprot.org/citations/24051248 | http://purl.uniprot.org/core/author | "Ramsey K.M."xsd:string |
| http://purl.uniprot.org/citations/24051248 | http://purl.uniprot.org/core/author | "Kuo H.Y."xsd:string |
| http://purl.uniprot.org/citations/24051248 | http://purl.uniprot.org/core/author | "Chandel N.S."xsd:string |
| http://purl.uniprot.org/citations/24051248 | http://purl.uniprot.org/core/author | "Goetzman E."xsd:string |
| http://purl.uniprot.org/citations/24051248 | http://purl.uniprot.org/core/author | "Sena L.A."xsd:string |
| http://purl.uniprot.org/citations/24051248 | http://purl.uniprot.org/core/author | "Peek C.B."xsd:string |
| http://purl.uniprot.org/citations/24051248 | http://purl.uniprot.org/core/author | "Affinati A.H."xsd:string |
| http://purl.uniprot.org/citations/24051248 | http://purl.uniprot.org/core/author | "Bacsik D.J."xsd:string |
| http://purl.uniprot.org/citations/24051248 | http://purl.uniprot.org/core/author | "Levine D.C."xsd:string |
| http://purl.uniprot.org/citations/24051248 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24051248 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/24051248 | http://purl.uniprot.org/core/pages | "1243417"xsd:string |