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http://purl.uniprot.org/citations/24051655http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/24051655http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/24051655http://www.w3.org/2000/01/rdf-schema#comment"Auxin is a major plant hormone that controls most aspects of plant growth and development. Auxin is perceived by two distinct classes of receptors: transport inhibitor response 1 (TIR1, or auxin-related F-box (AFB)) and auxin/indole-3-acetic acid (AUX/IAA) coreceptors, that control transcriptional responses to auxin, and the auxin-binding protein 1 (ABP1), that controls a wide variety of growth and developmental processes. To date, the mode of action of ABP1 is still poorly understood and its functional interaction with TIR1/AFB-AUX/IAA coreceptors remains elusive. Here we combine genetic and biochemical approaches to gain insight into the integration of these two pathways. We find that ABP1 is genetically upstream of TIR1/AFBs; ABP1 knockdown leads to an enhanced degradation of AUX/IAA repressors, independently of its effects on endocytosis, through the SCF(TIR1/AFB) E3 ubiquitin ligase pathway. Combining positive and negative regulation of SCF ubiquitin-dependent pathways might be a common mechanism conferring tight control of hormone-mediated responses."xsd:string
http://purl.uniprot.org/citations/24051655http://purl.org/dc/terms/identifier"doi:10.1038/ncomms3496"xsd:string
http://purl.uniprot.org/citations/24051655http://purl.org/dc/terms/identifier"doi:10.1038/ncomms3496"xsd:string
http://purl.uniprot.org/citations/24051655http://purl.uniprot.org/core/author"Genschik P."xsd:string
http://purl.uniprot.org/citations/24051655http://purl.uniprot.org/core/author"Genschik P."xsd:string
http://purl.uniprot.org/citations/24051655http://purl.uniprot.org/core/author"Lechner E."xsd:string
http://purl.uniprot.org/citations/24051655http://purl.uniprot.org/core/author"Lechner E."xsd:string
http://purl.uniprot.org/citations/24051655http://purl.uniprot.org/core/author"Muller P."xsd:string
http://purl.uniprot.org/citations/24051655http://purl.uniprot.org/core/author"Muller P."xsd:string
http://purl.uniprot.org/citations/24051655http://purl.uniprot.org/core/author"Paque S."xsd:string
http://purl.uniprot.org/citations/24051655http://purl.uniprot.org/core/author"Paque S."xsd:string
http://purl.uniprot.org/citations/24051655http://purl.uniprot.org/core/author"Perrot-Rechenmann C."xsd:string
http://purl.uniprot.org/citations/24051655http://purl.uniprot.org/core/author"Perrot-Rechenmann C."xsd:string
http://purl.uniprot.org/citations/24051655http://purl.uniprot.org/core/author"Quettier A.L."xsd:string
http://purl.uniprot.org/citations/24051655http://purl.uniprot.org/core/author"Quettier A.L."xsd:string
http://purl.uniprot.org/citations/24051655http://purl.uniprot.org/core/author"Stierle V."xsd:string
http://purl.uniprot.org/citations/24051655http://purl.uniprot.org/core/author"Stierle V."xsd:string
http://purl.uniprot.org/citations/24051655http://purl.uniprot.org/core/author"Tromas A."xsd:string
http://purl.uniprot.org/citations/24051655http://purl.uniprot.org/core/author"Tromas A."xsd:string
http://purl.uniprot.org/citations/24051655http://purl.uniprot.org/core/date"2013"xsd:gYear
http://purl.uniprot.org/citations/24051655http://purl.uniprot.org/core/date"2013"xsd:gYear
http://purl.uniprot.org/citations/24051655http://purl.uniprot.org/core/name"Nat. Commun."xsd:string
http://purl.uniprot.org/citations/24051655http://purl.uniprot.org/core/name"Nat. Commun."xsd:string