| http://purl.uniprot.org/citations/2405250 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2405250 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin-6 (IL-6) is one of the major mediators of inflammation, and its expression is inducible by the other inflammatory lymphokines, interleukin-1 (IL-1) and tumor necrosis factor alpha (TNF-alpha). We demonstrate that a common IL-6 promoter element, termed inflammatory lymphokine-responsive element (ILRE), is important for induction of IL-6 gene expression by IL-1 and TNF-alpha despite possible differences in the mechanisms of action of these lymphokines. Remarkably, the ILRE sequence, located between -73 to -63 relative to the mRNA cap site, is highly homologous to NF-kappa B transcription factor-binding motifs and binds an IL-1-TNF-alpha-inducible nuclear factor; the sequence specificities, binding characteristics, and subcellular localizations of this factor are indistinguishable from those of NF-kappa B. In addition, mutations of the ILRE sequence which impair the binding of this nuclear factor abolished the induction of IL-6 gene expression by IL-1 and TNF-alpha in vivo. These results indicate that a nuclear factor indistinguishable from NF-kappa B is involved in the transcriptional activation of the IL-6 gene by IL-1 and TNF-alpha."xsd:string |
| http://purl.uniprot.org/citations/2405250 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.10.2.561-568.1990"xsd:string |
| http://purl.uniprot.org/citations/2405250 | http://purl.uniprot.org/core/author | "Okamoto S."xsd:string |
| http://purl.uniprot.org/citations/2405250 | http://purl.uniprot.org/core/author | "Watanabe T."xsd:string |
| http://purl.uniprot.org/citations/2405250 | http://purl.uniprot.org/core/author | "Shimizu H."xsd:string |
| http://purl.uniprot.org/citations/2405250 | http://purl.uniprot.org/core/author | "Yamamoto K."xsd:string |
| http://purl.uniprot.org/citations/2405250 | http://purl.uniprot.org/core/author | "Mitomo K."xsd:string |
| http://purl.uniprot.org/citations/2405250 | http://purl.uniprot.org/core/date | "1990"xsd:gYear |
| http://purl.uniprot.org/citations/2405250 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/2405250 | http://purl.uniprot.org/core/pages | "561-568"xsd:string |
| http://purl.uniprot.org/citations/2405250 | http://purl.uniprot.org/core/title | "Involvement of a NF-kappa B-like transcription factor in the activation of the interleukin-6 gene by inflammatory lymphokines."xsd:string |
| http://purl.uniprot.org/citations/2405250 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/2405250 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/2405250 |
| http://purl.uniprot.org/citations/2405250 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/2405250 |
| http://purl.uniprot.org/uniprot/#_P19838-mappedCitation-2405250 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/2405250 |
| http://purl.uniprot.org/uniprot/#_P51965-mappedCitation-2405250 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/2405250 |
| http://purl.uniprot.org/uniprot/#_Q13042-mappedCitation-2405250 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/2405250 |
| http://purl.uniprot.org/uniprot/#_P51668-mappedCitation-2405250 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/2405250 |
| http://purl.uniprot.org/uniprot/#_O00762-mappedCitation-2405250 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/2405250 |
| http://purl.uniprot.org/uniprot/#_P17676-mappedCitation-2405250 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/2405250 |
| http://purl.uniprot.org/uniprot/#_O95231-mappedCitation-2405250 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/2405250 |
| http://purl.uniprot.org/uniprot/#_P05231-mappedCitation-2405250 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/2405250 |
| http://purl.uniprot.org/uniprot/#_P30260-mappedCitation-2405250 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/2405250 |
| http://purl.uniprot.org/uniprot/#_Q04206-mappedCitation-2405250 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/2405250 |