| http://purl.uniprot.org/citations/24055710 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24055710 | http://www.w3.org/2000/01/rdf-schema#comment | "Class II transactivator (CIITA) plays a critical role in controlling major histocompatibility complex (MHC) class II gene expression. In this study, two novel alternatively spliced variants of human interferon (IFN)-γ-inducible CIITA, one missing exon 7 (CIITAΔE7), the other with TAG inserted at exon 4/5 junction (CIITA-TAG), were identified and characterized. Both variants are naturally occurring since they are present in primary cells. Unlike CIITA-TAG, CIITAΔE7 is expressed more abundantly in lung adenocarcinoma A549 cells than in the non-transformed counterpart BEAS-2B cells following IFN-γ stimulation. Transfection experiments showed that CIITAΔE7 induced a markedly lower level of surface HLA-DR, -DP, -DQ expression than CIITA-TAG in A549 cells but not in BEAS-2B cells, although both variants elicited similar amounts of total DR, DP, and DQ proteins. This differential effect was correlated with, in A549 cells, decreased expression of Ii and HLA-DM genes, along with increased expression of HLA-DO genes. Ii and HLA-DM are chaperons assisting in HLA class II assembly, while HLA-DO functions to inhibit endosomal peptide loading and HLA class II membrane transport. These findings raise the possibility that CIITAΔE7 interacts with unknown cancer-associated factors to selectively modulate genes involved in the assembly and transport of HLA class II molecules."xsd:string |
| http://purl.uniprot.org/citations/24055710 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2013.09.066"xsd:string |
| http://purl.uniprot.org/citations/24055710 | http://purl.uniprot.org/core/author | "Chang C.C."xsd:string |
| http://purl.uniprot.org/citations/24055710 | http://purl.uniprot.org/core/author | "Li C.H."xsd:string |
| http://purl.uniprot.org/citations/24055710 | http://purl.uniprot.org/core/author | "Chiu B.L."xsd:string |
| http://purl.uniprot.org/citations/24055710 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24055710 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/24055710 | http://purl.uniprot.org/core/pages | "190-195"xsd:string |
| http://purl.uniprot.org/citations/24055710 | http://purl.uniprot.org/core/title | "Selective modulation of MHC class II chaperons by a novel IFN-gamma-inducible class II transactivator variant in lung adenocarcinoma A549 cells."xsd:string |
| http://purl.uniprot.org/citations/24055710 | http://purl.uniprot.org/core/volume | "440"xsd:string |
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