| http://purl.uniprot.org/citations/24056518 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24056518 | http://www.w3.org/2000/01/rdf-schema#comment | "ORM (yeast)-like protein isoform 3 (ORMDL3) has recently been identified as a candidate gene for susceptibility to asthma; however, the mechanisms by which it contributes to asthma pathogenesis are not well understood. Here we demonstrate a functional role for ORMDL3 in eosinophils in the context of allergic inflammation. Eosinophils recruited to the airways of allergen-challenged mice express ORMDL3. ORMDL3 expression in bone marrow eosinophils is localized in the endoplasmic reticulum and is induced by interleukin-3 and eotaxin-1. Overexpression of ORMDL3 in eosinophils causes increased rolling, distinct cytoskeletal rearrangement, extracellular signal-regulated kinase (1/2) phosphorylation and nuclear translocation of nuclear factor kappa B. Knockdown of ORMDL3 significantly inhibits activation-induced cell shape changes, adhesion and recruitment to sites of inflammation in vivo, combined with reduced expression of CD49d and CD18. In addition, ORMDL3 regulates interleukin-3-induced expression of CD48 and CD48-mediated eosinophil degranulation. These studies show that ORMDL3 regulates eosinophil trafficking, recruitment and degranulation, further elucidating a role for this molecule in allergic asthma and potentially other eosinophilic disorders."xsd:string |
| http://purl.uniprot.org/citations/24056518 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms3479"xsd:string |
| http://purl.uniprot.org/citations/24056518 | http://purl.uniprot.org/core/author | "Rao A."xsd:string |
| http://purl.uniprot.org/citations/24056518 | http://purl.uniprot.org/core/author | "Rao S.P."xsd:string |
| http://purl.uniprot.org/citations/24056518 | http://purl.uniprot.org/core/author | "Kang B.N."xsd:string |
| http://purl.uniprot.org/citations/24056518 | http://purl.uniprot.org/core/author | "Sriramarao P."xsd:string |
| http://purl.uniprot.org/citations/24056518 | http://purl.uniprot.org/core/author | "Ha S.G."xsd:string |
| http://purl.uniprot.org/citations/24056518 | http://purl.uniprot.org/core/author | "Ge X.N."xsd:string |
| http://purl.uniprot.org/citations/24056518 | http://purl.uniprot.org/core/author | "Bahaie N.S."xsd:string |
| http://purl.uniprot.org/citations/24056518 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24056518 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/24056518 | http://purl.uniprot.org/core/pages | "2479"xsd:string |
| http://purl.uniprot.org/citations/24056518 | http://purl.uniprot.org/core/title | "ORMDL3 promotes eosinophil trafficking and activation via regulation of integrins and CD48."xsd:string |
| http://purl.uniprot.org/citations/24056518 | http://purl.uniprot.org/core/volume | "4"xsd:string |
| http://purl.uniprot.org/citations/24056518 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24056518 |
| http://purl.uniprot.org/citations/24056518 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24056518 |
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| http://purl.uniprot.org/uniprot/#_P18181-mappedCitation-24056518 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24056518 |
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| http://purl.uniprot.org/uniprot/#_Q8C2T1-mappedCitation-24056518 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24056518 |
| http://purl.uniprot.org/uniprot/#_Q9R1N8-mappedCitation-24056518 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24056518 |
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