| http://purl.uniprot.org/citations/24057179 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24057179 | http://www.w3.org/2000/01/rdf-schema#comment | "To investigate the association of tag-SNPs and haplotype structures of the CIDEA gene with obesity in a Han Chinese population. Five single nucleotide polymorphisms (SNPs) (rs1154588/V115F, rs4796955/SNP1, rs8092502/SNP2, rs12962340/SNP3 and rs7230480/SNP4) in the CIDEA gene were genotyped in a case-control study. Genotyping was performed using the sequenom matrix-assisted laser desorption/ionization time-of-flight mass spectrometry iPLEX platform. There were significant differences between the obese and control groups in genotype distributions of V115F (P < 0.001), SNP1 (P = 0.006) and SNP2 (P = 0.005). Carriers of V115F-TT, SNP1-GG and SNP2-CC genotypes had a 2.84-fold (95 % CI 1.73-4.66), 2.19-fold (95 % CI 1.09-4.38) and 4.37-fold (95 % CI 1.21-15.08) increased risk for obesity, respectively. Haplotype analysis showed that GTTC (SNP1/SNP2/V115F/SNP4) had 1.41-fold (95 % CI 1.02-1.95) increased risk for obesity; whereas, haplotype TTGC had 0.48-fold (95 % CI 0.24-0.96) decreased risk for obesity. Using the multifactor dimensionality reduction method, the best model including SNP1, SNP2, V115F and SNP4 polymorphisms was identified with a maximum testing accuracy to 59.32 % and a perfect cross-validation consistency of 10/10 (P = 0.011). Logistic analysis indicated that there was a significant interaction between SNP1 and V115F associated with obesity. Subjects having both genotypes of SNP1/GG and V115F/TT were more susceptible to obesity in the Han Chinese population (OR 2.66, 95 %: 1.22-5.80). Genotypes of V115F/TT, SNP1/GG and SNP2/CC and haplotype GTTC of CIDEA gene were identified as risk factors for obesity in the Han Chinese population. The interaction between SNP1 and V115F could play a joint role in the development of obesity."xsd:string |
| http://purl.uniprot.org/citations/24057179 | http://purl.org/dc/terms/identifier | "doi:10.1007/s11033-013-2671-7"xsd:string |
| http://purl.uniprot.org/citations/24057179 | http://purl.uniprot.org/core/author | "Dai Y."xsd:string |
| http://purl.uniprot.org/citations/24057179 | http://purl.uniprot.org/core/author | "Wu J."xsd:string |
| http://purl.uniprot.org/citations/24057179 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/24057179 | http://purl.uniprot.org/core/author | "Zhang L."xsd:string |
| http://purl.uniprot.org/citations/24057179 | http://purl.uniprot.org/core/author | "Wang W."xsd:string |
| http://purl.uniprot.org/citations/24057179 | http://purl.uniprot.org/core/author | "Russell A."xsd:string |
| http://purl.uniprot.org/citations/24057179 | http://purl.uniprot.org/core/author | "Song M."xsd:string |
| http://purl.uniprot.org/citations/24057179 | http://purl.uniprot.org/core/author | "Bian L."xsd:string |
| http://purl.uniprot.org/citations/24057179 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24057179 | http://purl.uniprot.org/core/name | "Mol Biol Rep"xsd:string |
| http://purl.uniprot.org/citations/24057179 | http://purl.uniprot.org/core/pages | "5691-5699"xsd:string |
| http://purl.uniprot.org/citations/24057179 | http://purl.uniprot.org/core/title | "The genetic contribution of CIDEA polymorphisms, haplotypes and loci interaction to obesity in a Han Chinese population."xsd:string |
| http://purl.uniprot.org/citations/24057179 | http://purl.uniprot.org/core/volume | "40"xsd:string |
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