| http://purl.uniprot.org/citations/24058409 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24058409 | http://www.w3.org/2000/01/rdf-schema#comment | "Cone photopigments (opsins) are crucial elements of, and the first detection module in, color vision. Individual opsins have different wavelength sensitivity patterns, and the temporal and spatial expression patterns of opsins are unique and stringently regulated. Long and middle wavelength-sensitive (L/M) opsins are of the same phylogenetic type. Although the roles of thyroid hormone/TRß2 and COUP-TFs in the transcriptional regulation of L/M opsins have been explored, the detailed mechanisms, including the target sequence in the enhancer of L/M opsins, have not been revealed. We aimed to reveal molecular mechanisms of L/M opsins in vertebrates. Using several human red opsin enhancer/promoter-luciferase reporter constructs, we found that TRß2 increased luciferase activities through the 5'-UTR and intron 3-4 region, whereas the presence of T3 affected only the intron 3-4 region-dependent luciferase activity. Furthermore, COUP-TFII suppressed intron 3-4 region-dependent luciferase activities. However, luciferase expression driven by the mouse M opsin intron 3-4 region was only slightly increased by TRß2, and rather enhanced by COUP-TFII. To determine whether these differential responses reflect differences between primates and rodents, we examined the enhancer/promoter region of the red opsin of the common marmoset. Interestingly, while TRß2 increased 5'-UTR- or intron 3-4 region-driven luciferase expression, as observed for the human red opsin, expression of the latter luciferase was not suppressed by COUP-TFII. In fact, immunostaining of common marmoset retinal sections revealed expression of COUP-TFII and red opsin in the cone cells."xsd:string |
| http://purl.uniprot.org/citations/24058409 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0072065"xsd:string |
| http://purl.uniprot.org/citations/24058409 | http://purl.uniprot.org/core/author | "Itoh T."xsd:string |
| http://purl.uniprot.org/citations/24058409 | http://purl.uniprot.org/core/author | "Tanaka Y."xsd:string |
| http://purl.uniprot.org/citations/24058409 | http://purl.uniprot.org/core/author | "Watanabe S."xsd:string |
| http://purl.uniprot.org/citations/24058409 | http://purl.uniprot.org/core/author | "Iida A."xsd:string |
| http://purl.uniprot.org/citations/24058409 | http://purl.uniprot.org/core/author | "Iwagawa T."xsd:string |
| http://purl.uniprot.org/citations/24058409 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24058409 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/24058409 | http://purl.uniprot.org/core/pages | "e72065"xsd:string |
| http://purl.uniprot.org/citations/24058409 | http://purl.uniprot.org/core/title | "Enhancer/promoter activities of the long/middle wavelength-sensitive opsins of vertebrates mediated by thyroid hormone receptor beta2 and COUP-TFII."xsd:string |
| http://purl.uniprot.org/citations/24058409 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/24058409 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24058409 |
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| http://purl.uniprot.org/uniprot/#_A0A0R5RIB5-mappedCitation-24058409 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24058409 |
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| http://purl.uniprot.org/uniprot/#_B6ZGR7-mappedCitation-24058409 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24058409 |