| http://purl.uniprot.org/citations/24058482 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24058482 | http://www.w3.org/2000/01/rdf-schema#comment | "The MICA/B genes (MHC class I chain related genes A and B) encode for non conventional class I HLA molecules which have no role in antigen presentation. MICA/B are up-regulated by different stress conditions such as heat-shock, oxidative stress, neoplasic transformation and viral infection. Particularly, MICA/B are expressed in enterocytes where they can mediate enterocyte apoptosis when recognised by the activating NKG2D receptor present on intraepithelial lymphocytes. This mechanism was suggested to play a major pathogenic role in active celiac disease (CD). Due to the importance of MICA/B in CD pathogenesis we studied their expression in duodenal tissue from CD patients. By immunofluorescence confocal microscopy and flow cytometry we established that MICA/B was mainly intracellularly located in enterocytes. In addition, we identified MICA/B(+) T cells in both the intraepithelial and lamina propria compartments. We also found MICA/B(+) B cells, plasma cells and some macrophages in the lamina propria. The pattern of MICA/B staining in mucosal tissue in severe enteropathy was similar to that found in in vitro models of cellular stress. In such models, MICA/B were located in stress granules that are associated to the oxidative and ER stress response observed in active CD enteropathy. Our results suggest that expression of MICA/B in the intestinal mucosa of CD patients is linked to disregulation of mucosa homeostasis in which the stress response plays an active role."xsd:string |
| http://purl.uniprot.org/citations/24058482 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0073658"xsd:string |
| http://purl.uniprot.org/citations/24058482 | http://purl.uniprot.org/core/author | "Fuertes M."xsd:string |
| http://purl.uniprot.org/citations/24058482 | http://purl.uniprot.org/core/author | "Zwirner N.W."xsd:string |
| http://purl.uniprot.org/citations/24058482 | http://purl.uniprot.org/core/author | "Guzman L."xsd:string |
| http://purl.uniprot.org/citations/24058482 | http://purl.uniprot.org/core/author | "Chirdo F.G."xsd:string |
| http://purl.uniprot.org/citations/24058482 | http://purl.uniprot.org/core/author | "Bondar C."xsd:string |
| http://purl.uniprot.org/citations/24058482 | http://purl.uniprot.org/core/author | "Chopita N."xsd:string |
| http://purl.uniprot.org/citations/24058482 | http://purl.uniprot.org/core/author | "Allegretti Y.L."xsd:string |
| http://purl.uniprot.org/citations/24058482 | http://purl.uniprot.org/core/author | "Cueto Rua E."xsd:string |
| http://purl.uniprot.org/citations/24058482 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24058482 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/24058482 | http://purl.uniprot.org/core/pages | "e73658"xsd:string |
| http://purl.uniprot.org/citations/24058482 | http://purl.uniprot.org/core/title | "Broad MICA/B expression in the small bowel mucosa: a link between cellular stress and celiac disease."xsd:string |
| http://purl.uniprot.org/citations/24058482 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/24058482 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24058482 |
| http://purl.uniprot.org/citations/24058482 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24058482 |
| http://purl.uniprot.org/uniprot/#_A0A0F6UUZ2-mappedCitation-24058482 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24058482 |
| http://purl.uniprot.org/uniprot/#_A0A0M3LB88-mappedCitation-24058482 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24058482 |
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| http://purl.uniprot.org/uniprot/#_A0A0M3LB98-mappedCitation-24058482 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24058482 |
| http://purl.uniprot.org/uniprot/#_A0A0M3LBA3-mappedCitation-24058482 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24058482 |
| http://purl.uniprot.org/uniprot/#_A0A0M3LBA6-mappedCitation-24058482 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24058482 |
| http://purl.uniprot.org/uniprot/#_A0A0M3LBB1-mappedCitation-24058482 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24058482 |