| http://purl.uniprot.org/citations/24058535 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24058535 | http://www.w3.org/2000/01/rdf-schema#comment | "Parathyroid hormone (PTH) plays a critical role in the regulation of chondrogenesis. In this study, we have found for the first time that Runt-related transcription factor 1 (Runx1) contributes to PTH-induced chondrogenesis. Upon PTH treatment, limb bud mesenchymal progenitor cells in micromass culture showed an enhanced chondrogenesis, which was associated with a significant increase of chondrogenic marker gene expression, such as type II collagen and type X collagen. Runx1 was also exclusively expressed in cells treated with PTH at the onset stage of chondrogenesis. Knockdown of Runx1 completely blunted PTH-mediated chondrogenesis. Furthermore, PTH induced Runx1 expression and chondrogenesis were markedly reduced by inhibition of protein kinase A (PKA) signaling. Taken together, our present study indicates that chondrogenesis induced by PTH in mesenchymal progenitor cells is mediated by Runx1, which involves the activation of PKA. These data provide a novel insight into understanding the molecular mechanisms behind PTH-enhanced cartilage regeneration."xsd:string |
| http://purl.uniprot.org/citations/24058535 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0074255"xsd:string |
| http://purl.uniprot.org/citations/24058535 | http://purl.uniprot.org/core/author | "Dong Y."xsd:string |
| http://purl.uniprot.org/citations/24058535 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/24058535 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/24058535 | http://purl.uniprot.org/core/author | "Wang X."xsd:string |
| http://purl.uniprot.org/citations/24058535 | http://purl.uniprot.org/core/author | "Zhu Z."xsd:string |
| http://purl.uniprot.org/citations/24058535 | http://purl.uniprot.org/core/author | "Holz J.D."xsd:string |
| http://purl.uniprot.org/citations/24058535 | http://purl.uniprot.org/core/author | "Rutkowski T."xsd:string |
| http://purl.uniprot.org/citations/24058535 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24058535 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/24058535 | http://purl.uniprot.org/core/pages | "e74255"xsd:string |
| http://purl.uniprot.org/citations/24058535 | http://purl.uniprot.org/core/title | "Runx1 is critical for PTH-induced onset of mesenchymal progenitor cell chondrogenic differentiation."xsd:string |
| http://purl.uniprot.org/citations/24058535 | http://purl.uniprot.org/core/volume | "8"xsd:string |
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