| http://purl.uniprot.org/citations/24058613 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24058613 | http://www.w3.org/2000/01/rdf-schema#comment | "Regulatory T cells (Tregs) maintain immune homeostasis by limiting inflammatory responses. TRAF6 plays a key role in the regulation of innate and adaptive immunity by mediating signals from various receptors including the T-cell receptor (TCR). T cell-specific deletion of TRAF6 has been shown to induce multiorgan inflammatory disease, but the role of TRAF6 in Tregs remains to be investigated. Here, we generated Treg-specific TRAF6-deficient mice using Foxp3-Cre and TRAF6-flox mice. Treg-specific TRAF6-deficient (cKO) mice developed allergic skin diseases, arthritis, lymphadenopathy and hyper IgE phenotypes. Although TRAF6-deficient Tregs possess similar in vitro suppression activity compared to wild-type Tregs, TRAF6-deficient Tregs did not suppress colitis in lymphopenic mice very efficiently due to reduced number of Foxp3-positive cells. In addition, the fraction of TRAF6-deficient Tregs was reduced compared with wild-type Tregs in female cKO mice without inflammation. Moreover, adoptive transfer of Foxp3 (+) Tregs into Rag2(-/-) mice revealed that TRAF6-deficient Tregs converted into Foxp3(-) cells more rapidly than WT Tregs under lymphopenic conditions. Fate-mapping analysis also revealed that conversion of Tregs from Foxp3(+) to Foxp3(-) (exFoxp3 cells) was accelerated in TRAF6-deficient Tregs. These data indicate that TRAF6 in Tregs plays important roles in the maintenance of Foxp3 in Tregs and in the suppression of pathogenic Th2 type conversion of Tregs."xsd:string |
| http://purl.uniprot.org/citations/24058613 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0074639"xsd:string |
| http://purl.uniprot.org/citations/24058613 | http://purl.uniprot.org/core/author | "Kobayashi T."xsd:string |
| http://purl.uniprot.org/citations/24058613 | http://purl.uniprot.org/core/author | "Kotani H."xsd:string |
| http://purl.uniprot.org/citations/24058613 | http://purl.uniprot.org/core/author | "Choi Y."xsd:string |
| http://purl.uniprot.org/citations/24058613 | http://purl.uniprot.org/core/author | "Kondo T."xsd:string |
| http://purl.uniprot.org/citations/24058613 | http://purl.uniprot.org/core/author | "Morita R."xsd:string |
| http://purl.uniprot.org/citations/24058613 | http://purl.uniprot.org/core/author | "Yoshimura A."xsd:string |
| http://purl.uniprot.org/citations/24058613 | http://purl.uniprot.org/core/author | "Walsh M."xsd:string |
| http://purl.uniprot.org/citations/24058613 | http://purl.uniprot.org/core/author | "Fehling H.J."xsd:string |
| http://purl.uniprot.org/citations/24058613 | http://purl.uniprot.org/core/author | "Tsuruta S."xsd:string |
| http://purl.uniprot.org/citations/24058613 | http://purl.uniprot.org/core/author | "Luche H."xsd:string |
| http://purl.uniprot.org/citations/24058613 | http://purl.uniprot.org/core/author | "Muto G."xsd:string |
| http://purl.uniprot.org/citations/24058613 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24058613 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/24058613 | http://purl.uniprot.org/core/pages | "e74639"xsd:string |
| http://purl.uniprot.org/citations/24058613 | http://purl.uniprot.org/core/title | "TRAF6 is essential for maintenance of regulatory T cells that suppress Th2 type autoimmunity."xsd:string |
| http://purl.uniprot.org/citations/24058613 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/24058613 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24058613 |
| http://purl.uniprot.org/citations/24058613 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24058613 |
| http://purl.uniprot.org/uniprot/#_A0A3Q4EC35-mappedCitation-24058613 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24058613 |
| http://purl.uniprot.org/uniprot/#_A0A3Q4EC46-mappedCitation-24058613 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24058613 |
| http://purl.uniprot.org/uniprot/#_A0A3Q4EI60-mappedCitation-24058613 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24058613 |
| http://purl.uniprot.org/uniprot/#_A0A3Q4L2R0-mappedCitation-24058613 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24058613 |