| http://purl.uniprot.org/citations/24061617 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24061617 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin-36α (IL-36α) has been found to have a prominent role in the pathogenesis of inflammatory disorders; however, little is known about the role of IL-36α in cancer. In this study, we investigated the expression, prognostic value, and the underlying antitumor mechanism of IL-36α in hepatocellular carcinoma (HCC). From immunohistochemistry analysis, IL-36α expression was lower in poorly differentiated HCC cells. In clinicopathological analysis, low IL-36α expression significantly correlated with tumor size, histological differentiation, tumor stage, and vascular invasion, and low intratumoral IL-36α expression had significantly worse overall survival rates and shorter disease-free survival rates. Moreover, intratumoral IL-36α expression was an independent risk factor for overall survival. Consecutive sections were used to detect CD3+, CD8+, and CD4+ tumor-infiltrating lymphocytes (TILs), and we found that high-IL-36α-expressing tumor tissues exhibited a significantly higher proportion of intratumoral CD3+ and CD8+ TILs, but not CD4+ TILs. Our in vitro model confirmed that supernatant from IL-36α-overexpressing human HCC cells had an increased capacity to recruit CD3+ and CD8+ T cells. Consistently, mouse HCC cells engineered to overexpress IL-36α demonstrated markedly delayed growth in vivo, as well as higher levels of intratumoral CD3+ and CD8+ TILs, compared with control mice. In vitro chemotaxis analysis also showed that mouse HCC cells overexpressing IL-36α could recruit more number of CD3+ and CD8+ T cells. These results show that IL-36α expression may play a pivotal role in determining the prognosis of patients with HCC, which we attribute to the activation of adaptive T cell immunity, especially CD8+ T cell immune response."xsd:string |
| http://purl.uniprot.org/citations/24061617 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00262-013-1471-1"xsd:string |
| http://purl.uniprot.org/citations/24061617 | http://purl.uniprot.org/core/author | "Chen J.G."xsd:string |
| http://purl.uniprot.org/citations/24061617 | http://purl.uniprot.org/core/author | "Zhang X.F."xsd:string |
| http://purl.uniprot.org/citations/24061617 | http://purl.uniprot.org/core/author | "Lv L."xsd:string |
| http://purl.uniprot.org/citations/24061617 | http://purl.uniprot.org/core/author | "Pan K."xsd:string |
| http://purl.uniprot.org/citations/24061617 | http://purl.uniprot.org/core/author | "Jiang S.S."xsd:string |
| http://purl.uniprot.org/citations/24061617 | http://purl.uniprot.org/core/author | "Zheng H.X."xsd:string |
| http://purl.uniprot.org/citations/24061617 | http://purl.uniprot.org/core/author | "Li J.J."xsd:string |
| http://purl.uniprot.org/citations/24061617 | http://purl.uniprot.org/core/author | "Zhao J.J."xsd:string |
| http://purl.uniprot.org/citations/24061617 | http://purl.uniprot.org/core/author | "Wang D.D."xsd:string |
| http://purl.uniprot.org/citations/24061617 | http://purl.uniprot.org/core/author | "Pan Q.Z."xsd:string |
| http://purl.uniprot.org/citations/24061617 | http://purl.uniprot.org/core/author | "Xia J.C."xsd:string |
| http://purl.uniprot.org/citations/24061617 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24061617 | http://purl.uniprot.org/core/name | "Cancer Immunol Immunother"xsd:string |
| http://purl.uniprot.org/citations/24061617 | http://purl.uniprot.org/core/pages | "1675-1685"xsd:string |
| http://purl.uniprot.org/citations/24061617 | http://purl.uniprot.org/core/title | "Decreased expression of interleukin-36alpha correlates with poor prognosis in hepatocellular carcinoma."xsd:string |
| http://purl.uniprot.org/citations/24061617 | http://purl.uniprot.org/core/volume | "62"xsd:string |
| http://purl.uniprot.org/citations/24061617 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24061617 |
| http://purl.uniprot.org/citations/24061617 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/24061617 |
| http://purl.uniprot.org/uniprot/#_Q9UHA7-mappedCitation-24061617 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24061617 |
| http://purl.uniprot.org/uniprot/Q9UHA7 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/24061617 |