| http://purl.uniprot.org/citations/2406558 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2406558 | http://www.w3.org/2000/01/rdf-schema#comment | "Saccharomyces cerevisiae RNA polymerase II conditional mutants that selectively disrupt the synthesis of specific mRNAs were isolated. At the permissive temperature, several of the mutants were inositol auxotrophs as a result of inadequate induction of INO1 transcription. The transcriptional defects exhibited by one of these Ino-mutants (rpb2-2) were further investigated. The induction of GAL10 and HIS4 transcription in rpb2-2 strains was similar to that of wild-type strains, in contrast to the lack of induction of INO1 transcription. When shifted to the nonpermissive temperature, cells containing rpb2-2 continued to accumulate some mRNAs but not others. Together, these results indicate that transcription of specific genes can be disrupted by RNA polymerase II mutations. The rpb2-2 allele alters an amino acid residue that occurs in a highly conserved segment of the RPB2 protein and that is shared by homologous subunits in other species."xsd:string |
| http://purl.uniprot.org/citations/2406558 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.10.3.1010-1016.1990"xsd:string |
| http://purl.uniprot.org/citations/2406558 | http://purl.uniprot.org/core/author | "Young R.A."xsd:string |
| http://purl.uniprot.org/citations/2406558 | http://purl.uniprot.org/core/author | "Nonet M."xsd:string |
| http://purl.uniprot.org/citations/2406558 | http://purl.uniprot.org/core/author | "Scafe C."xsd:string |
| http://purl.uniprot.org/citations/2406558 | http://purl.uniprot.org/core/date | "1990"xsd:gYear |
| http://purl.uniprot.org/citations/2406558 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/2406558 | http://purl.uniprot.org/core/pages | "1010-1016"xsd:string |
| http://purl.uniprot.org/citations/2406558 | http://purl.uniprot.org/core/title | "RNA polymerase II mutants defective in transcription of a subset of genes."xsd:string |
| http://purl.uniprot.org/citations/2406558 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/2406558 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/2406558 |
| http://purl.uniprot.org/citations/2406558 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/2406558 |
| http://purl.uniprot.org/uniprot/P08518#attribution-CDA4E20D09BFF18B416041DEF32C1A02 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/2406558 |
| http://purl.uniprot.org/uniprot/#_P08518-mappedCitation-2406558 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/2406558 |
| http://purl.uniprot.org/uniprot/P08518 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/2406558 |