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| http://purl.uniprot.org/citations/24066180 | http://www.w3.org/2000/01/rdf-schema#comment | "A hypometabolic state can be induced in mice by 5'-AMP administration. Previously we proposed that an underlying mechanism for this hypometabolism is linked to reduced erythrocyte oxygen transport function due to 5'-AMP uptake altering the cellular adenylate equilibrium. To test this hypothesis, we generated mice deficient in adenosine monophosphate deaminase 3 (AMPD3), the key catabolic enzyme for 5'-AMP in erythrocytes. Mice deficient in AMPD3 maintained AMPD activities in all tissues except erythrocytes. Developmentally and morphologically, the Ampd3(-/-) mice were indistinguishable from their wild type siblings. The levels of ATP, ADP but not 5'-AMP in erythrocytes of Ampd3(-/-) mice were significantly elevated. Fasting blood glucose levels of the Ampd3(-/-) mice were comparable to wild type siblings. In comparison to wild type mice, the Ampd3(-/-) mice displayed a deeper hypometabolism with a significantly delayed average arousal time in response to 5'-AMP administration. Together, these findings demonstrate a central role of AMPD3 in the regulation of 5'-AMP mediated hypometabolism and further implicate erythrocytes in this behavioral response."xsd:string |
| http://purl.uniprot.org/citations/24066180 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0075418"xsd:string |
| http://purl.uniprot.org/citations/24066180 | http://purl.uniprot.org/core/author | "Lee C.C."xsd:string |
| http://purl.uniprot.org/citations/24066180 | http://purl.uniprot.org/core/author | "Zhao Z."xsd:string |
| http://purl.uniprot.org/citations/24066180 | http://purl.uniprot.org/core/author | "Nath V."xsd:string |
| http://purl.uniprot.org/citations/24066180 | http://purl.uniprot.org/core/author | "Daniels I.S."xsd:string |
| http://purl.uniprot.org/citations/24066180 | http://purl.uniprot.org/core/author | "O Brien W.G."xsd:string |
| http://purl.uniprot.org/citations/24066180 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24066180 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/24066180 | http://purl.uniprot.org/core/pages | "e75418"xsd:string |
| http://purl.uniprot.org/citations/24066180 | http://purl.uniprot.org/core/title | "AMP deaminase 3 deficiency enhanced 5'-AMP induction of hypometabolism."xsd:string |
| http://purl.uniprot.org/citations/24066180 | http://purl.uniprot.org/core/volume | "8"xsd:string |
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