| http://purl.uniprot.org/citations/24067967 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/24067967 | http://www.w3.org/2000/01/rdf-schema#comment | "Herpes simplex virus 1 (HSV-1) Us11 protein is a double-stranded RNA-binding protein that suppresses type I interferon production through the inhibition of the cytoplasmic RNA sensor RIG-I. Whether additional cellular mediators are involved in this suppression remains to be determined. In this study, we report on the requirement of cellular double-stranded RNA-binding protein PACT for Us11-mediated perturbation of type I interferon production. Us11 associates with PACT tightly to prevent it from binding with and activating RIG-I. The Us11-deficient HSV-1 was indistinguishable from the Us11-proficient virus in the suppression of interferon production when PACT was compromised. More importantly, HSV-1-induced activation of interferon production was abrogated in PACT knockout murine embryonic fibroblasts. Our findings suggest a new mechanism for viral evasion of innate immunity through which a viral double-stranded RNA-binding protein interacts with PACT to circumvent type I interferon production. This mechanism might also be used by other PACT-binding viral interferon-antagonizing proteins such as Ebola virus VP35 and influenza A virus NS1."xsd:string |
| http://purl.uniprot.org/citations/24067967 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.02564-13"xsd:string |
| http://purl.uniprot.org/citations/24067967 | http://purl.uniprot.org/core/author | "Liu X."xsd:string |
| http://purl.uniprot.org/citations/24067967 | http://purl.uniprot.org/core/author | "Jin D.Y."xsd:string |
| http://purl.uniprot.org/citations/24067967 | http://purl.uniprot.org/core/author | "Au S.W."xsd:string |
| http://purl.uniprot.org/citations/24067967 | http://purl.uniprot.org/core/author | "Mohr I."xsd:string |
| http://purl.uniprot.org/citations/24067967 | http://purl.uniprot.org/core/author | "Chan C.P."xsd:string |
| http://purl.uniprot.org/citations/24067967 | http://purl.uniprot.org/core/author | "Kok K.H."xsd:string |
| http://purl.uniprot.org/citations/24067967 | http://purl.uniprot.org/core/author | "Kew C."xsd:string |
| http://purl.uniprot.org/citations/24067967 | http://purl.uniprot.org/core/author | "Lui P.Y."xsd:string |
| http://purl.uniprot.org/citations/24067967 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/24067967 | http://purl.uniprot.org/core/name | "J Virol"xsd:string |
| http://purl.uniprot.org/citations/24067967 | http://purl.uniprot.org/core/pages | "13141-13149"xsd:string |
| http://purl.uniprot.org/citations/24067967 | http://purl.uniprot.org/core/title | "Suppression of PACT-induced type I interferon production by herpes simplex virus 1 Us11 protein."xsd:string |
| http://purl.uniprot.org/citations/24067967 | http://purl.uniprot.org/core/volume | "87"xsd:string |
| http://purl.uniprot.org/citations/24067967 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/24067967 |
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| http://purl.uniprot.org/uniprot/#_A0A7I2V2I8-mappedCitation-24067967 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24067967 |
| http://purl.uniprot.org/uniprot/#_B5BUQ5-mappedCitation-24067967 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24067967 |
| http://purl.uniprot.org/uniprot/#_B4DJC7-mappedCitation-24067967 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24067967 |
| http://purl.uniprot.org/uniprot/#_G5E9Q4-mappedCitation-24067967 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24067967 |
| http://purl.uniprot.org/uniprot/#_P01574-mappedCitation-24067967 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24067967 |
| http://purl.uniprot.org/uniprot/#_O75569-mappedCitation-24067967 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/24067967 |